DegronMD - Q8WVE6(TMEM171)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A310V	TCGA-BR-4184	STAD	TCGA	EKENA	DEG_APCC_KENBOX_2	306:310	Mutation altering degron motif	0.5825
p.A310T	TCGA-BR-4361	STAD	TCGA	EKENA	DEG_APCC_KENBOX_2	306:310	Mutation altering degron motif	0.6028
p.S256R	TCGA-BR-8372	STAD	TCGA	PPSY	ITCH	251:254	Mutation rewiring degron network	0.2778
p.S256R	DO47873	STAD	ICGC	PPSY	ITCH	251:254	Mutation rewiring degron network	0.2778
p.S234Y	TCGA-BS-A0UV	UCEC	TCGA	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1389
p.S234Y	DO42793	UCEC	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1389
p.P247L	TCGA-CM-6162	COAD	TCGA	PPSY	ITCH	251:254	Mutation rewiring degron network	0.2222
p.P247L	DO8479	COAD	ICGC	PPSY	ITCH	251:254	Mutation rewiring degron network	0.2222
p.P221S	TCGA-D7-5577	STAD	TCGA	PPPY	ITCH	224:227	Mutation rewiring degron network	0.25
p.P221S	DO38631	STAD	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.25
p.I218L	TCGA-E9-A1N9	BRCA	TCGA	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1667
p.I218L	DO2569	BRCA	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1667
p.S231F	TCGA-FI-A2D0	UCEC	TCGA	PPPY	ITCH	224:227	Mutation rewiring degron network	0.2222
p.S231F	DO43891	UCEC	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.2222
p.S234F	TCGA-GN-A4U8	SKCM	TCGA	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1389
p.S234F	DO47320	SKCM	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1389
p.S244G	DO233882	GACA	ICGC	PPSY	ITCH	251:254	Mutation rewiring degron network	0.1389
p.G214D	DO229051	LICA	ICGC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.0556
p.P293L	DO220906	MELA	ICGC	PPRY	ITCH	301:304	Mutation rewiring degron network	0.1111
p.G241R	DO222868	MELA	ICGC	PPSY	ITCH	251:254	Mutation rewiring degron network	0.0556
p.A309T	DO38887	STAD	ICGC	EKENA	DEG_APCC_KENBOX_2	306:310	Mutation altering degron motif	0.7139
p.A309V	DO38328	STAD	ICGC	EKENA	DEG_APCC_KENBOX_2	306:310	Mutation altering degron motif	0.6936
p.N250K	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	251:254	Mutation rewiring degron network	0.3056
p.N250K	ACH-000438	Lung Cancer	CCLE	PPSY	ITCH	251:254	Mutation rewiring degron network	0.3056
p.N250K	LU-65	lung	COSMIC	PPSY	ITCH	251:254	Mutation rewiring degron network	0.3056
p.F314L	SIDM00193	Colorectal Carcinoma	GDSC	EKENA	DEG_APCC_KENBOX_2	306:310	Mutation rewiring degron network	0.2222
p.F314L	SIDM00193	Colorectal Carcinoma	GDSC	PPRY	ITCH	301:304	Mutation rewiring degron network	0.0556
p.F314L	ACH-000991	Colon/Colorectal Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	306:310	Mutation rewiring degron network	0.2222
p.F314L	ACH-000991	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	301:304	Mutation rewiring degron network	0.0556
p.F314L	SNU-81	large intestine	COSMIC	EKENA	DEG_APCC_KENBOX_2	306:310	Mutation rewiring degron network	0.2222
p.F314L	SNU-81	large intestine	COSMIC	PPRY	ITCH	301:304	Mutation rewiring degron network	0.0556
p.V236I	SIDM00878	Breast Carcinoma	GDSC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.0833
p.A235V	SIDM01442	Glioma	GDSC	PPPY	ITCH	224:227	Mutation rewiring degron network	0.1111
p.F313L	SNU-81	large intestine	COSMIC	EKENA	DEG_APCC_KENBOX_2	306:310	Mutation blocking phosphorylation signal	0.6944
p.F313L	SNU-81	large intestine	COSMIC	PPRY	ITCH	301:304	Mutation blocking phosphorylation signal	0.5278

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM171

UniProt ID: Q8WVE6

Entrez ID: 134285

Protein name: Transmembrane protein 171

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM171 in