DegronMD

Uniprot ID: Q8WVE6

Source protein: Transmembrane protein 171

Source gene: TMEM171

Class: DEG_APCC_KENBOX_2

Location: 306:310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9638

ASA_SCORE: 95.66

COIL: 0.3776

CONS_SCORE: 0.5537

DSS_SCORE: 0.6504

HELIX: 0.601

FCONS_SCORE: 1.1377

RIG_SCORE: 0.6811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A310V	TCGA-BR-4184	STAD	TCGA	EKENA	DEG_APCC_KENBOX_2	0.5825
p.A310T	TCGA-BR-4361	STAD	TCGA	EKENA	DEG_APCC_KENBOX_2	0.6028
p.A309T	DO38887	STAD	ICGC	EKENA	DEG_APCC_KENBOX_2	0.7139
p.A309V	DO38328	STAD	ICGC	EKENA	DEG_APCC_KENBOX_2	0.6936
p.F314L	SIDM00193	Colorectal Carcinoma	GDSC	EKENA	DEG_APCC_KENBOX_2	0.2222
p.F314L	ACH-000991	Colon/Colorectal Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	0.2222
p.F314L	SNU-81	large_intestine	COSMIC	EKENA	DEG_APCC_KENBOX_2	0.2222
p.F313L	SNU-81	large_intestine	COSMIC	EKENA	DEG_APCC_KENBOX_2	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07283	Trichohyalin	DEG_APCC_KENBOX_2	1230:1234	EKENA	APC,CDC20,FZR1	0.9598	More...
Q13158	FAS-associated death domain protein	DEG_APCC_KENBOX_2	152:156	EKENA	APC,CDC20,FZR1	0.6103	More...
Q8N0X2	Sperm-associated antigen 16 protein	DEG_APCC_KENBOX_2	283:287	EKENA	APC,CDC20,FZR1	0.5296	More...
Q8WVE6	Transmembrane protein 171	DEG_APCC_KENBOX_2	306:310	EKENA	APC,CDC20,FZR1	0.9638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons