DegronMD

Uniprot ID: Q07283

Source protein: Trichohyalin

Source gene: TCHH

Class: DEG_APCC_KENBOX_2

Location: 1230:1234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9598

ASA_SCORE: 124.8

COIL: 0.6906

CONS_SCORE: 0.3873

DSS_SCORE: 0.3797

HELIX: 0.2924

FCONS_SCORE: 1.3918

RIG_SCORE: 0.7146

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1235F	TCGA-64-5779	LUAD	TCGA	EKENA	DEG_APCC_KENBOX_2	0.3056
p.V1235F	DO24930	LUAD	ICGC	EKENA	DEG_APCC_KENBOX_2	0.3056
p.R1220C	TCGA-DU-6392	LGG	TCGA	EKENA	DEG_APCC_KENBOX_2	0.0556
p.R1220C	DO22237	LGG	ICGC	EKENA	DEG_APCC_KENBOX_2	0.0556
p.R1220C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EKENA	DEG_APCC_KENBOX_2	0.0556
p.R1220C	ACH-002256	Leukemia	CCLE	EKENA	DEG_APCC_KENBOX_2	0.0556
p.R1220C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	EKENA	DEG_APCC_KENBOX_2	0.0556
p.N1238S	TCGA-E6-A1LX	UCEC	TCGA	EKENA	DEG_APCC_KENBOX_2	0.2222
p.N1238S	DO41020	UCEC	ICGC	EKENA	DEG_APCC_KENBOX_2	0.2222
p.R1236C	DO233731	GACA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.2778
p.R1236C	SIDM01611	Endometrial Carcinoma	GDSC	EKENA	DEG_APCC_KENBOX_2	0.2778
p.R1236C	ACH-000996	Endometrial/Uterine Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	0.2778
p.L1223V	SIDM00502	B-Lymphoblastic Leukemia	GDSC	EKENA	DEG_APCC_KENBOX_2	0.1389
p.L1223V	ACH-000157	Lymphoma	CCLE	EKENA	DEG_APCC_KENBOX_2	0.1389
p.L1223V	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	EKENA	DEG_APCC_KENBOX_2	0.1389
p.E1232G	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENA	DEG_APCC_KENBOX_2	0.7199
p.E1232G	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	EKENA	DEG_APCC_KENBOX_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07283	Trichohyalin	DEG_APCC_KENBOX_2	1230:1234	EKENA	APC,CDC20,FZR1	0.9598	More...
Q13158	FAS-associated death domain protein	DEG_APCC_KENBOX_2	152:156	EKENA	APC,CDC20,FZR1	0.6103	More...
Q8N0X2	Sperm-associated antigen 16 protein	DEG_APCC_KENBOX_2	283:287	EKENA	APC,CDC20,FZR1	0.5296	More...
Q8WVE6	Transmembrane protein 171	DEG_APCC_KENBOX_2	306:310	EKENA	APC,CDC20,FZR1	0.9638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons