DegronMD - Q8N0X2(SPAG16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R297C	TCGA-AO-A1KO	BRCA	TCGA	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.0556
p.R297C	DO4038	BRCA	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.0556
p.R297C	DO36881	READ	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.0556
p.R282C	TCGA-DK-A6AW	BLCA	TCGA	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.3056
p.R282H	TCGA-DU-6392	LGG	TCGA	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.3056
p.R282H	TCGA-EI-6882	READ	TCGA	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.3056
p.R282H	DO22237	LGG	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.3056
p.R282H	DO36531	READ	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.3056
p.E285K	TCGA-EE-A2A5	SKCM	TCGA	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation altering degron motif	0.7022
p.E285K	DO37941	SKCM	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation altering degron motif	0.7022
p.G290V	TCGA-FA-A6HO	DLBC	TCGA	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.25
p.R282L	DO229028	LICA	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.3056
p.K289N	DO229177	LMS	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.2778
p.V284L	DO26719	LUSC	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation altering degron motif	0.6765
p.K284I	DO51956	PRAD	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation altering degron motif	0.7531
p.P288S	DO50280	SKCM	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.3056
p.P291R	DO229259	THCA	ICGC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.2222
p.E283Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation altering degron motif	0.5633
p.E283Q	ACH-000824	Esophageal Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation altering degron motif	0.5633
p.E283Q	KYSE-510	oesophagus	COSMIC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation altering degron motif	0.5633
p.S281I	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.2778
p.S281I	ACH-000675	Lung Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.2778
p.S281I	NCI-H1734	lung	COSMIC	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.2778
p.H280Y	ACH-001566	Skin Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	283:287	Mutation rewiring degron network	0.25

Kaplan plot for SPAG16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPAG16

UniProt ID: Q8N0X2

Entrez ID: 79582

Protein name: Sperm-associated antigen 16 protein (Pf20 protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPAG16 in