DegronMD

Uniprot ID: Q8N0X2

Source protein: Sperm-associated antigen 16 protein

Source gene: SPAG16

Class: DEG_APCC_KENBOX_2

Location: 283:287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5296

ASA_SCORE: 84.54

COIL: 0.7502

CONS_SCORE: 0.5898

DSS_SCORE: 0.7458

HELIX: 0.0308

FCONS_SCORE: 1.0434

RIG_SCORE: 0.5866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R297C	TCGA-AO-A1KO	BRCA	TCGA	EKENA	DEG_APCC_KENBOX_2	0.0556
p.R297C	DO4038	BRCA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.0556
p.R297C	DO36881	READ	ICGC	EKENA	DEG_APCC_KENBOX_2	0.0556
p.R282C	TCGA-DK-A6AW	BLCA	TCGA	EKENA	DEG_APCC_KENBOX_2	0.3056
p.R282H	TCGA-DU-6392	LGG	TCGA	EKENA	DEG_APCC_KENBOX_2	0.3056
p.R282H	TCGA-EI-6882	READ	TCGA	EKENA	DEG_APCC_KENBOX_2	0.3056
p.R282H	DO22237	LGG	ICGC	EKENA	DEG_APCC_KENBOX_2	0.3056
p.R282H	DO36531	READ	ICGC	EKENA	DEG_APCC_KENBOX_2	0.3056
p.E285K	TCGA-EE-A2A5	SKCM	TCGA	EKENA	DEG_APCC_KENBOX_2	0.7022
p.E285K	DO37941	SKCM	ICGC	EKENA	DEG_APCC_KENBOX_2	0.7022
p.G290V	TCGA-FA-A6HO	DLBC	TCGA	EKENA	DEG_APCC_KENBOX_2	0.25
p.R282L	DO229028	LICA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.3056
p.K289N	DO229177	LMS	ICGC	EKENA	DEG_APCC_KENBOX_2	0.2778
p.V284L	DO26719	LUSC	ICGC	EKENA	DEG_APCC_KENBOX_2	0.6765
p.K284I	DO51956	PRAD	ICGC	EKENA	DEG_APCC_KENBOX_2	0.7531
p.P288S	DO50280	SKCM	ICGC	EKENA	DEG_APCC_KENBOX_2	0.3056
p.P291R	DO229259	THCA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.2222
p.E283Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	EKENA	DEG_APCC_KENBOX_2	0.5633
p.E283Q	ACH-000824	Esophageal Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	0.5633
p.E283Q	KYSE-510	oesophagus	COSMIC	EKENA	DEG_APCC_KENBOX_2	0.5633
p.S281I	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	EKENA	DEG_APCC_KENBOX_2	0.2778
p.S281I	ACH-000675	Lung Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	0.2778
p.S281I	NCI-H1734	lung	COSMIC	EKENA	DEG_APCC_KENBOX_2	0.2778
p.H280Y	ACH-001566	Skin Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07283	Trichohyalin	DEG_APCC_KENBOX_2	1230:1234	EKENA	APC,CDC20,FZR1	0.9598	More...
Q13158	FAS-associated death domain protein	DEG_APCC_KENBOX_2	152:156	EKENA	APC,CDC20,FZR1	0.6103	More...
Q8N0X2	Sperm-associated antigen 16 protein	DEG_APCC_KENBOX_2	283:287	EKENA	APC,CDC20,FZR1	0.5296	More...
Q8WVE6	Transmembrane protein 171	DEG_APCC_KENBOX_2	306:310	EKENA	APC,CDC20,FZR1	0.9638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons