DegronMD

Uniprot ID: Q13158

Source protein: FAS-associated death domain protein

Source gene: FADD

Class: DEG_APCC_KENBOX_2

Location: 152:156

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6103

ASA_SCORE: 97.26

COIL: 0.8374

CONS_SCORE: 0.6246

DSS_SCORE: 0.2256

HELIX: 0.1452

FCONS_SCORE: 0.895

RIG_SCORE: 0.7718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G163V	TCGA-46-3765	LUSC	TCGA	EKENA	DEG_APCC_KENBOX_2	0.1389
p.G163V	DO26959	LUSC	ICGC	EKENA	DEG_APCC_KENBOX_2	0.1389
p.V162A	TCGA-AA-3845	COAD	TCGA	EKENA	DEG_APCC_KENBOX_2	0.1667
p.V162A	DO10020	COAD	ICGC	EKENA	DEG_APCC_KENBOX_2	0.1667
p.R142W	TCGA-B5-A3FC	UCEC	TCGA	EKENA	DEG_APCC_KENBOX_2	0.0556
p.R142W	DO41871	UCEC	ICGC	EKENA	DEG_APCC_KENBOX_2	0.0556
p.K149N	TCGA-CF-A47V	BLCA	TCGA	EKENA	DEG_APCC_KENBOX_2	0.6944
p.K149N	TCGA-CF-A47Y	BLCA	TCGA	EKENA	DEG_APCC_KENBOX_2	0.6944
p.K149N	DO44053	BLCA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.6944
p.K149N	DO44050	BLCA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.6944
p.I147M	TCGA-NJ-A4YP	LUAD	TCGA	EKENA	DEG_APCC_KENBOX_2	0.1944
p.I147M	DO218943	LUAD	ICGC	EKENA	DEG_APCC_KENBOX_2	0.1944
p.A156T	DO222765	COCA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.6028
p.A156T	DO23172	LINC	ICGC	EKENA	DEG_APCC_KENBOX_2	0.6028
p.R142Q	DO222765	COCA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.0556
p.L145P	DO233869	GACA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.1389
p.A164S	DO229034	LICA	ICGC	EKENA	DEG_APCC_KENBOX_2	0.1111
p.T151I	DO231186	LUSC	ICGC	EKENA	DEG_APCC_KENBOX_2	0.3056
p.A159T	DO41199	UCEC	ICGC	EKENA	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07283	Trichohyalin	DEG_APCC_KENBOX_2	1230:1234	EKENA	APC,CDC20,FZR1	0.9598	More...
Q13158	FAS-associated death domain protein	DEG_APCC_KENBOX_2	152:156	EKENA	APC,CDC20,FZR1	0.6103	More...
Q8N0X2	Sperm-associated antigen 16 protein	DEG_APCC_KENBOX_2	283:287	EKENA	APC,CDC20,FZR1	0.5296	More...
Q8WVE6	Transmembrane protein 171	DEG_APCC_KENBOX_2	306:310	EKENA	APC,CDC20,FZR1	0.9638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons