DegronMD - Q13158(FADD)

GO - Biological processes (BP): activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; behavioral response to cocaine [GO:0048148]; cellular response to mechanical stimulus [GO:0071260]; death-inducing signaling complex assembly [GO:0071550]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; innate immune response [GO:0045087]; kidney development [GO:0001822]; lymph node development [GO:0048535]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of activation-induced cell death of T cells [GO:0070236]; negative regulation of necroptotic process [GO:0060546]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of apoptotic process [GO:0043065]; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000454]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; response to morphine [GO:0043278]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; TRAIL-activated apoptotic signaling pathway [GO:0036462] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G163V	TCGA-46-3765	LUSC	TCGA	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.1389
p.G163V	DO26959	LUSC	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.1389
p.V162A	TCGA-AA-3845	COAD	TCGA	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.1667
p.V162A	DO10020	COAD	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.1667
p.R142W	TCGA-B5-A3FC	UCEC	TCGA	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.0556
p.R142W	DO41871	UCEC	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.0556
p.K149N	TCGA-CF-A47V	BLCA	TCGA	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation blocking ubiquitination signal	0.6944
p.K149N	TCGA-CF-A47Y	BLCA	TCGA	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation blocking ubiquitination signal	0.6944
p.K149N	DO44053	BLCA	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation blocking ubiquitination signal	0.6944
p.K149N	DO44050	BLCA	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation blocking ubiquitination signal	0.6944
p.I147M	TCGA-NJ-A4YP	LUAD	TCGA	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.1944
p.I147M	DO218943	LUAD	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.1944
p.A156T	DO222765	COCA	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation altering degron motif	0.6028
p.A156T	DO23172	LINC	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation altering degron motif	0.6028
p.R142Q	DO222765	COCA	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.0556
p.L145P	DO233869	GACA	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.1389
p.A164S	DO229034	LICA	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.1111
p.T151I	DO231186	LUSC	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.3056
p.A159T	DO41199	UCEC	ICGC	EKENA	DEG_APCC_KENBOX_2	152:156	Mutation rewiring degron network	0.25

Kaplan plot for FADD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FADD

UniProt ID: Q13158

Entrez ID: 8772

Protein name: FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FADD in