DegronMD - Q07283(TCHH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1235F	TCGA-64-5779	LUAD	TCGA	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.3056
p.V1235F	DO24930	LUAD	ICGC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.3056
p.R1220C	TCGA-DU-6392	LGG	TCGA	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.0556
p.R1220C	DO22237	LGG	ICGC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.0556
p.R1220C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.0556
p.R1220C	ACH-002256	Leukemia	CCLE	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.0556
p.R1220C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.0556
p.N1238S	TCGA-E6-A1LX	UCEC	TCGA	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.2222
p.N1238S	DO41020	UCEC	ICGC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.2222
p.R1236C	DO233731	GACA	ICGC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.2778
p.R1236C	SIDM01611	Endometrial Carcinoma	GDSC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.2778
p.R1236C	ACH-000996	Endometrial/Uterine Cancer	CCLE	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.2778
p.L1223V	SIDM00502	B-Lymphoblastic Leukemia	GDSC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.1389
p.L1223V	ACH-000157	Lymphoma	CCLE	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.1389
p.L1223V	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation rewiring degron network	0.1389
p.E1232G	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation altering degron motif	0.7199
p.E1232G	Farage	haematopoietic and lymphoid tissue	COSMIC	EKENA	DEG_APCC_KENBOX_2	1230:1234	Mutation altering degron motif	0.7199

Kaplan plot for TCHH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCHH

UniProt ID: Q07283

Entrez ID: 7062

Protein name: Trichohyalin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCHH in