DegronMD - P30876(POLR2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D846N	TCGA-60-2703	LUSC	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1111
p.D846N	TCGA-DA-A1HY	SKCM	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1111
p.D846N	TCGA-HD-7754	HNSC	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1111
p.D846N	DO222817	BTCA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1111
p.D846N	DO15094	HNSC	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1111
p.D846N	DO27715	LUSC	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1111
p.D846N	DO37409	SKCM	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1111
p.D849N	TCGA-AC-A23H	BRCA	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1944
p.D849N	DO2401	BRCA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1944
p.P82S	TCGA-D1-A167	UCEC	TCGA	PPRY	ITCH	81:84	Mutation altering degron motif	0.6752
p.P82S	DO40978	UCEC	ICGC	PPRY	ITCH	81:84	Mutation altering degron motif	0.6752
p.G76V	TCGA-DF-A2KU	UCEC	TCGA	PPRY	ITCH	81:84	Mutation rewiring degron network	0.1944
p.G76V	DO223286	UCEC	ICGC	PPRY	ITCH	81:84	Mutation rewiring degron network	0.1944
p.P874H	TCGA-GN-A26C	SKCM	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1389
p.P874H	DO37782	SKCM	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1389
p.D864N	TCGA-V5-A7RB	ESCA	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation altering degron motif	0.5821
p.S94F	TCGA-W3-AA1V	SKCM	TCGA	PPRY	ITCH	81:84	Mutation rewiring degron network	0.0556
p.S94F	DO51276	SKCM	ICGC	PPRY	ITCH	81:84	Mutation rewiring degron network	0.0556
p.L853F	TCGA-ZF-A9R7	BLCA	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.3056
p.L853F	DO219064	BLCA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.3056
p.D864Y	DO222762	COCA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation altering degron motif	0.6214
p.D846Y	DO234251	ESAD	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.1111
p.P81Q	DO228905	LICA	ICGC	PPRY	ITCH	81:84	Mutation altering degron motif	0.7035
p.R859C	DO222595	MELA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation altering degron motif	0.719
p.G852V	DO49135	PACA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation rewiring degron network	0.2778
p.R83Q	DO232761	PBCA	ICGC	PPRY	ITCH	81:84	Mutation altering degron motif	0.6218
p.R83Q	SIDM00534	Colorectal Carcinoma	GDSC	PPRY	ITCH	81:84	Mutation altering degron motif	0.6218
p.R83Q	ACH-000986	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	81:84	Mutation altering degron motif	0.6218
p.R83Q	HT-115	large intestine	COSMIC	PPRY	ITCH	81:84	Mutation altering degron motif	0.6218
p.E80D	SIDM01943	Colorectal Carcinoma	GDSC	PPRY	ITCH	81:84	Mutation rewiring degron network	0.3056
p.R94H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPRY	ITCH	81:84	Mutation rewiring degron network	0.0556
p.P854S	KYSE-70	oesophagus	COSMIC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	854:867	Mutation altering degron motif	0.6752
p.R76Q	HT-115	large intestine	COSMIC	PPRY	ITCH	81:84	Mutation rewiring degron network	0.1944
p.L87F	KM12	large intestine	COSMIC	PPRY	ITCH	81:84	Mutation blocking ubiquitination signal	0.6944

Kaplan plot for POLR2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POLR2B

UniProt ID: P30876

Entrez ID: 5431

Protein name: DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POLR2B in