DegronMD

Uniprot ID: P30876

Source protein: DNA-directed RNA polymerase II subunit RPB2

Source gene: POLR2B

Class: DEG_ODPH_VHL_1

Location: 854:867

E3 ligase: VHL

DEGRON score: 0.6171

ASA_SCORE: 39.8

COIL: 0.5631

CONS_SCORE: 0.6122

DSS_SCORE: 0.3354

HELIX: 0.0091

FCONS_SCORE: 1.1333

RIG_SCORE: 0.7639

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D846N	TCGA-60-2703	LUSC	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1111
p.D846N	TCGA-DA-A1HY	SKCM	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1111
p.D846N	TCGA-HD-7754	HNSC	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1111
p.D846N	DO222817	BTCA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1111
p.D846N	DO15094	HNSC	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1111
p.D846N	DO27715	LUSC	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1111
p.D846N	DO37409	SKCM	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1111
p.D849N	TCGA-AC-A23H	BRCA	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1944
p.D849N	DO2401	BRCA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1944
p.P874H	TCGA-GN-A26C	SKCM	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1389
p.P874H	DO37782	SKCM	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1389
p.D864N	TCGA-V5-A7RB	ESCA	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.5821
p.L853F	TCGA-ZF-A9R7	BLCA	TCGA	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.3056
p.L853F	DO219064	BLCA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.3056
p.D864Y	DO222762	COCA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.6214
p.D846Y	DO234251	ESAD	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.1111
p.R859C	DO222595	MELA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.719
p.G852V	DO49135	PACA	ICGC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.2778
p.P854S	KYSE-70	oesophagus	COSMIC	IAPGVRVSGDDVII	DEG_ODPH_VHL_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30876	DNA-directed RNA polymerase II subunit RPB2	DEG_ODPH_VHL_1	854:867	IAPGVRVSGDDVII	VHL	0.6171	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons