DegronMD - O95793(STAU1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S70R	TCGA-4Z-AA89	BLCA	TCGA	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.3056
p.S70R	DO218991	BLCA	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.3056
p.K86N	TCGA-A5-A2K5	UCEC	TCGA	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation substituting flanking lysine	0.1667
p.S26Y	TCGA-AJ-A5DW	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.S26Y	DO50075	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.P373S	TCGA-AP-A0LM	UCEC	TCGA	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation altering degron motif	0.6752
p.C81R	TCGA-AZ-4615	COAD	TCGA	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1944
p.C81R	DO7977	COAD	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1944
p.P114L	TCGA-B5-A1MX	UCEC	TCGA	PPRY	ITCH	113:116	Mutation altering degron motif	0.7582
p.L27F	TCGA-BR-8680	STAD	TCGA	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0833
p.L27F	DO220877	MELA	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0833
p.L27F	DO47769	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0833
p.K375N	TCGA-BS-A0UF	UCEC	TCGA	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation altering degron motif	0.6918
p.Q358R	TCGA-D1-A15X	UCEC	TCGA	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.0556
p.E76G	TCGA-D3-A3C8	SKCM	TCGA	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation altering degron motif	0.7199
p.E76G	DO47636	SKCM	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation altering degron motif	0.7199
p.P50L	TCGA-D3-A8GM	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.P50L	DO50288	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.M107T	TCGA-D7-A6EY	STAD	TCGA	PPRY	ITCH	113:116	Mutation rewiring degron network	0.1667
p.T62I	TCGA-FA-A86F	DLBC	TCGA	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.0833
p.T62I	DO219892	DLBC	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.0833
p.E45V	TCGA-MX-A663	STAD	TCGA	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1944
p.E45V	DO51748	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1944
p.S41F	TCGA-W3-A828	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.3056
p.S41F	DO51273	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.3056
p.E82V	DO49800	BLCA	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1667
p.M371I	DO2401	BRCA	ICGC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation altering degron motif	0.7618
p.Q47E	DO2067	BRCA	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1389
p.A360T	DO3542	BRCA	ICGC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.1111
p.P85S	DO8119	COAD	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.0833
p.V108L	DO233140	GACA	ICGC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.1944
p.R34M	DO233261	GACA	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.A124T	DO44440	HNSC	ICGC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.1111
p.P50T	DO228900	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.P43T	DO228948	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.25
p.Q80K	DO228971	LICA	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.2222
p.Q30K	DO228971	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1667
p.P38T	DO229019	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation altering degron motif	0.7031
p.Q47K	DO229027	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1389
p.A112E	DO229037	LICA	ICGC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.3056
p.V368I	DO220883	MELA	ICGC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation altering degron motif	0.7076
p.A370T	DO222407	MELA	ICGC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation altering degron motif	0.7139
p.R115Q	DO30490	OV	ICGC	PPRY	ITCH	113:116	Mutation altering degron motif	0.6218
p.K74T	DO46657	PAAD	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation altering degron motif	0.7306
p.R125W	DO220258	SARC	ICGC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.0833
p.K114E	DO37406	SKCM	ICGC	PPRY	ITCH	113:116	Mutation altering degron motif	0.7022
p.H69Y	DO37499	SKCM	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.2778
p.P125L	DO47425	SKCM	ICGC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.0833
p.P125L	SIDM00845	Burkitt's Lymphoma	GDSC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.0833
p.M26T	DO50118	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.0556
p.A68S	DO229245	THCA	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.25
p.S106G	DO223282	UCEC	ICGC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.1389
p.N120H	DO43154	UCEC	ICGC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.2222
p.T63I	DO41999	UCEC	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1111
p.P33L	DO41999	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.25
p.E82D	DO42608	UCEC	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1667
p.D70N	DO43907	UCEC	ICGC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.3056
p.M82V	SIDM01023	Acute Myeloid Leukemia	GDSC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1667
p.M82V	SIDM00214	Colorectal Carcinoma	GDSC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1667
p.M82V	ACH-000006	Leukemia	CCLE	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1667
p.M82V	ACH-000955	Colon/Colorectal Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1667
p.M82V	MONO-MAC-6	haematopoietic and lymphoid tissue	COSMIC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1667
p.M82V	SNU-407	large intestine	COSMIC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1667
p.A79S	SIDM00127	Oral Cavity Carcinoma	GDSC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.25
p.A79S	ACH-002250	Head and Neck Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.25
p.A79S	JHU-022	upper aerodigestive tract	COSMIC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.25
p.L126F	SIDM00855	Other Sarcomas	GDSC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.0556
p.L126F	ACH-000375	Kidney Cancer	CCLE	PPRY	ITCH	113:116	Mutation rewiring degron network	0.0556
p.L126F	G-402	soft tissue	COSMIC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.0556
p.S34I	SIDM00193	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.S34I	ACH-000991	Colon/Colorectal Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.S34I	SNU-81	large intestine	COSMIC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.2778
p.R115M	SIDM01611	Endometrial Carcinoma	GDSC	PPRY	ITCH	113:116	Mutation altering degron motif	0.7521
p.C81F	SIDM01611	Endometrial Carcinoma	GDSC	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1944
p.C81F	ACH-000996	Endometrial/Uterine Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1944
p.A66E	ACH-001814	Bone Cancer	CCLE	ITPTVE	DEG_SCF_FBW7_2	71:76	Mutation rewiring degron network	0.1944
p.P371L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation altering degron motif	0.7582
p.L45F	G-402	soft tissue	COSMIC	PSTTS	DEG_SPOP_SBC_1	36:40	Mutation rewiring degron network	0.1944
p.P362L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.1667
p.E126K	NCI-H661	lung	COSMIC	PPRY	ITCH	113:116	Mutation rewiring degron network	0.0556
p.G380D	HMV-II	skin	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.1944
p.P365L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.25
p.G382D	HMV-II	skin	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation blocking ubiquitination signal	0.5833
p.A384S	HT-115	large intestine	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.0833
p.G379D	HMV-II	skin	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.2222
p.P363L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation blocking ubiquitination signal	0.6389
p.E385K	OE19	oesophagus	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.0556
p.A385S	HT-115	large intestine	COSMIC	SEEKTPIK	DEG_SCF_SKP2-CKS1_1	368:375	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAU1

UniProt ID: O95793

Entrez ID: 6780

Protein name: Double-stranded RNA-binding protein Staufen homolog 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAU1 in