DegronMD

Uniprot ID: O95793

Source protein: Double-stranded RNA-binding protein Staufen homolog 1

Source gene: STAU1

Class: DEG_SPOP_SBC_1

Location: 36:40

E3 ligase: SPOP

DEGRON score: 0.9778

ASA_SCORE: 79.5

COIL: 0.897

CONS_SCORE: 0.3805

DSS_SCORE: 0.5668

HELIX: 0.042

FCONS_SCORE: 0.8991

RIG_SCORE: 0.6369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S26Y	TCGA-AJ-A5DW	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.0556
p.S26Y	DO50075	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.L27F	TCGA-BR-8680	STAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.0833
p.L27F	DO220877	MELA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0833
p.L27F	DO47769	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0833
p.P50L	TCGA-D3-A8GM	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	0.0556
p.P50L	DO50288	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.E45V	TCGA-MX-A663	STAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.1944
p.E45V	DO51748	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.S41F	TCGA-W3-A828	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	0.3056
p.S41F	DO51273	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.Q47E	DO2067	BRCA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.R34M	DO233261	GACA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.P50T	DO228900	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.P43T	DO228948	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.25
p.Q30K	DO228971	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1667
p.P38T	DO229019	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7031
p.Q47K	DO229027	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.M26T	DO50118	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.P33L	DO41999	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.25
p.S34I	SIDM00193	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.S34I	ACH-000991	Colon/Colorectal Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.2778
p.S34I	SNU-81	large_intestine	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.L45F	G-402	soft_tissue	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with STAU1 mutations

All proteins holding degron of PSTTS