DegronMD

Uniprot ID: Q4G112

Source protein: Heat shock factor protein 5

Source gene: HSF5

Class: DEG_SPOP_SBC_1

Location: 271:275

E3 ligase: SPOP

DEGRON score: 0.9846

ASA_SCORE: 74.44

COIL: 0.8744

CONS_SCORE: 0.5337

DSS_SCORE: 0.477

HELIX: 0.0514

FCONS_SCORE: 1.0033

RIG_SCORE: 0.7291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P262L	TCGA-05-4410	LUAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.0833
p.P262L	TCGA-75-6214	LUAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.0833
p.P262L	DO25426	LUAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0833
p.P262L	DO24830	LUAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0833
p.V278A	TCGA-2W-A8YY	CESC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.25
p.V278A	DO223732	CESC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.25
p.V276A	TCGA-85-6798	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.3056
p.V276A	DO27295	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.S275Y	TCGA-AA-3977	COAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.712
p.S275Y	DO8730	COAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.712
p.S272N	TCGA-B5-A3FC	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.5958
p.S272N	DO41871	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.5958
p.Q280K	DO229022	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.Q279R	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.Q279R	ACH-000452	Esophageal Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.2222
p.Q279R	TE-8	oesophagus	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with HSF5 mutations

All proteins holding degron of PSTTS