DegronMD

Uniprot ID: P37198

Source protein: Nuclear pore glycoprotein p62

Source gene: NUP62

Class: DEG_SPOP_SBC_1

Location: 144:148

E3 ligase: SPOP

DEGRON score: 0.9919

ASA_SCORE: 82.5

COIL: 0.915

CONS_SCORE: 0.3409

DSS_SCORE: 0.4316

HELIX: 0.0266

FCONS_SCORE: 0.7578

RIG_SCORE: 0.7222

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G134D	TCGA-A5-A0G2	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.0556
p.G134D	DO41235	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.P137S	TCGA-A6-3807	COAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.1389
p.P137S	DO9034	COAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.F142S	TCGA-D1-A17Q	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.2778
p.F142S	DO41903	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.P137L	TCGA-EE-A2MR	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	0.1389
p.P137L	DO37819	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.G139S	DO229016	COCA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	DO229047	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	DO230934	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	DO231169	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00376	B-Lymphoblastic Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00338	Acute Myeloid Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01265	Plasma Cell Myeloma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00570	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00373	Endometrial Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00993	Plasma Cell Myeloma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00557	Neuroblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00617	Hepatocellular Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00572	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01203	Other Solid Cancers	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00611	Kidney Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00075	Non-Cancerous	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00535	Chondrosarcoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00304	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00602	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00496	Thyroid Gland Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00553	Acute Myeloid Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00267	Biliary Tract Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01242	Melanoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00590	Oral Cavity Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00394	Cervical Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00260	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00568	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00282	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00235	Kidney Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01118	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00054	Pancreatic Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00292	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00819	Kidney Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00252	Biliary Tract Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00240	Cervical Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00247	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00357	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00539	Esophageal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00574	Glioblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00876	Non-Cancerous	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00970	Bladder Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00988	Kidney Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00566	Oral Cavity Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00613	Glioblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00877	Breast Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00996	Thyroid Gland Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00233	T-Lymphoblastic Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00503	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01018	Hodgkin's Lymphoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00808	Burkitt's Lymphoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01608	Endometrial Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01659	Kidney Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01735	Biliary Tract Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01570	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00168	Head and Neck Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01577	Plasma Cell Myeloma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01444	Glioblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01472	Hepatocellular Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00248	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01445	Gastric Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01691	Chronic Myelogenous Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00173	Head and Neck Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00823	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01473	Plasma Cell Myeloma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01451	Pancreatic Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM00162	Biliary Tract Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G139S	SIDM01254	Burkitt's Lymphoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.G143D	DO233259	GACA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.F140L	DO232846	NACA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2222
p.T146N	DO229250	THCA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with NUP62 mutations

All proteins holding degron of PSTTS