DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PSTTS
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SPOP_SBC_1
Location:
1866:1870
E3 ligase:
SPOP
DEGRON score:
0.9365
ASA_SCORE:
83.24
COIL:
0.8876
CONS_SCORE:
0
DSS_SCORE:
0.5041
HELIX:
0.0268
FCONS_SCORE:
0
RIG_SCORE:
0.7108
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95793
Double-stranded RNA-binding protein Staufen homolog 1
DEG_SPOP_SBC_1
36:40
PSTTS
SPOP
0.9778
More...
P29558
RNA-binding motif, single-stranded-interacting protein 1
DEG_SPOP_SBC_1
39:43
PSTTS
SPOP
0.581
More...
P32238
Cholecystokinin receptor type A
DEG_SPOP_SBC_1
255:259
PSTTS
SPOP
0.709
More...
P37198
Nuclear pore glycoprotein p62
DEG_SPOP_SBC_1
144:148
PSTTS
SPOP
0.9919
More...
P49790
Nuclear pore complex protein Nup153
DEG_SPOP_SBC_1
113:117
PSTTS
SPOP
0.9869
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3686:3690
PSTTS
SPOP
0.7046
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
4119:4123
PSTTS
SPOP
0.859
More...
Q04900
Sialomucin core protein 24
DEG_SPOP_SBC_1
132:136
PSTTS
SPOP
0.5053
More...
Q5T6F2
Ubiquitin-associated protein 2
DEG_SPOP_SBC_1
674:678
PSTTS
SPOP
0.9729
More...
Q684P5
Rap1 GTPase-activating protein 2
DEG_SPOP_SBC_1
664:668
PSTTS
SPOP
0.998
More...
Q76I76
Protein phosphatase Slingshot homolog 2
DEG_SPOP_SBC_1
12:16
PSTTS
SPOP
0.9684
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
1196:1200
PSTTS
SPOP
0.9172
More...
Q99250
Sodium channel protein type 2 subunit alpha
DEG_SPOP_SBC_1
1967:1971
PSTTS
SPOP
0.97
More...
Q9HBB8
Cadherin-related family member 5
DEG_SPOP_SBC_1
491:495
PSTTS
SPOP
0.9709
More...
Q9NZP6
Nuclear pore-associated protein 1
DEG_SPOP_SBC_1
1046:1050
PSTTS
SPOP
0.998
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
800:804
PSTTS
SPOP
0.9364
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
1866:1870
PSTTS
SPOP
0.9365
More...
Q4G112
Heat shock factor protein 5
DEG_SPOP_SBC_1
271:275
PSTTS
SPOP
0.9846
More...