DegronMD - Q99250(SCN2A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G479W	TCGA-05-4410	LUAD	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.3056
p.G479W	DO25426	LUAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.3056
p.G481E	TCGA-20-1684	OV	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6087
p.G481E	TCGA-ER-A193	SKCM	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6087
p.G481E	DO32009	OV	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6087
p.G481E	DO47368	SKCM	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6087
p.D1952N	TCGA-55-8089	LUAD	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.1667
p.D1952N	DO23690	LUAD	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.1667
p.P1960A	TCGA-60-2723	LUSC	TCGA	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.1944
p.P1960A	TCGA-60-2723	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1389
p.P1960A	DO27152	LUSC	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.1944
p.P1960A	DO27152	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1389
p.R1902L	TCGA-62-A470	LUAD	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902L	DO24288	LUAD	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.S494I	TCGA-77-A5G7	LUSC	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.0833
p.S494I	DO50098	LUSC	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.0833
p.S486I	TCGA-85-8071	LUSC	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.3056
p.S486I	DO26755	LUSC	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.3056
p.D1935Y	TCGA-86-6851	LUAD	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.2222
p.D1935Y	DO23798	LUAD	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.2222
p.V1891I	TCGA-95-7039	LUAD	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.2222
p.V1891I	DO23907	LUAD	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.2222
p.D473N	TCGA-A5-A0G2	UCEC	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1389
p.D473N	DO234230	ESAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1389
p.D473N	DO41235	UCEC	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1389
p.T1145M	TCGA-A5-A0G2	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.2222
p.T1145M	DO41235	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.2222
p.T1949N	TCGA-AP-A0LM	UCEC	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.25
p.T1949N	DO43306	UCEC	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.25
p.R1902C	TCGA-B1-A47O	KIRP	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902C	TCGA-DX-A8BK	SARC	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902C	TCGA-FR-A2OS	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902C	TCGA-VQ-A94R	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902C	DO222523	COCA	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902C	DO51551	KIRP	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902C	DO220047	SARC	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902C	DO37876	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902C	DO222372	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.E1956D	TCGA-B5-A11E	UCEC	TCGA	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.0833
p.E1956D	TCGA-B5-A11E	UCEC	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.0556
p.E1956D	DO41644	UCEC	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.0833
p.E1956D	DO41644	UCEC	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.0556
p.T1897M	TCGA-BR-4184	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1897M	TCGA-EO-A22U	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1897M	TCGA-FC-7961	PRAD	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1897M	TCGA-VQ-A8P2	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1897M	DO233693	GACA	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1897M	DO46801	PRAD	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1897M	DO51761	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1897M	DO38328	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1897M	DO43755	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.T1966M	TCGA-BR-4280	STAD	TCGA	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation altering degron motif	0.7423
p.T1966M	DO38663	STAD	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation altering degron motif	0.7423
p.S487F	TCGA-BR-7959	STAD	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2778
p.S487F	DO38408	STAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2778
p.Y1893D	TCGA-BS-A0UF	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation blocking phosphorylation signal	0.7222
p.Y1893D	DO41488	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation blocking phosphorylation signal	0.7222
p.K1901Q	TCGA-BS-A0UF	UCEC	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.2778
p.K1901Q	DO41488	UCEC	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.2778
p.E1961D	TCGA-CA-6718	COAD	TCGA	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.2222
p.E1961D	TCGA-CA-6718	COAD	TCGA	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1667
p.E1961D	TCGA-F5-6814	READ	TCGA	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.2222
p.E1961D	TCGA-F5-6814	READ	TCGA	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1667
p.E1961D	DO7801	COAD	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.2222
p.E1961D	DO7801	COAD	ICGC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1667
p.E1961D	DO36556	READ	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.2222
p.E1961D	DO36556	READ	ICGC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1667
p.R1902H	TCGA-D3-A2JO	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.R1902H	DO47619	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.L493V	TCGA-D7-6527	STAD	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1111
p.L493V	DO38635	STAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1111
p.S1144N	TCGA-D8-A1JF	BRCA	TCGA	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.S1144N	DO6204	BRCA	ICGC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.P1888S	TCGA-DA-A95Z	SKCM	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.1389
p.P1888S	DO219481	SKCM	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.1389
p.G481R	TCGA-EE-A2GO	SKCM	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6457
p.G481R	DO37823	SKCM	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6457
p.G1942E	TCGA-EE-A3JD	SKCM	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation altering degron motif	0.6087
p.G1942E	DO50299	SKCM	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation altering degron motif	0.6087
p.S1974L	TCGA-FR-A3YN	SKCM	TCGA	PPSY	ITCH	1972:1975	Mutation altering degron motif	0.7667
p.S1974L	DO38111	SKCM	ICGC	PPSY	ITCH	1972:1975	Mutation altering degron motif	0.7667
p.S484L	TCGA-FR-A8YC	SKCM	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6556
p.S484L	DO50301	SKCM	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6556
p.D1935E	TCGA-FS-A4FD	SKCM	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.2222
p.D1935E	DO37699	SKCM	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.2222
p.S1886P	TCGA-HU-A4GX	STAD	TCGA	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.0833
p.S1886P	DO47757	STAD	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.0833
p.K492T	TCGA-HU-A4H2	STAD	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation substituting flanking lysine	0.25
p.K492T	DO47825	STAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation substituting flanking lysine	0.25
p.S1140L	TCGA-SY-A9G5	BLCA	TCGA	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.7667
p.S1140L	DO51906	BLCA	ICGC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.7667
p.P1972T	TCGA-VQ-A91Z	STAD	TCGA	PPSY	ITCH	1972:1975	Mutation altering degron motif	0.7031
p.P1972T	DO51792	STAD	ICGC	PPSY	ITCH	1972:1975	Mutation altering degron motif	0.7031
p.R472G	TCGA-W2-A7HH	PCPG	TCGA	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1111
p.T1899M	DO50307	ESAD	ICGC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation altering degron motif	0.8534
p.I1945M	DO234197	ESAD	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation altering degron motif	0.6507
p.V482G	DO233176	GACA	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.7532
p.V1978L	DO229027	LICA	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.1111
p.V1978L	DO229027	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1389
p.V1978L	DO229027	LICA	ICGC	PPSY	ITCH	1972:1975	Mutation rewiring degron network	0.25
p.G478V	DO229038	LICA	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2778
p.G478C	DO229041	LICA	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2778
p.G476C	DO229045	LICA	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2222
p.D1976Y	DO229008	LICA	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.1667
p.D1976Y	DO229008	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1944
p.D1976Y	DO229008	LICA	ICGC	PPSY	ITCH	1972:1975	Mutation rewiring degron network	0.3056
p.T1943K	DO50780	LIRI	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation altering degron motif	0.7306
p.I480K	DO230934	LUSC	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.7531
p.I480K	DO224581	LUSC	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.7531
p.P1973S	DO231204	LUSC	ICGC	PPSY	ITCH	1972:1975	Mutation altering degron motif	0.6752
p.S488L	DO222696	MELA	ICGC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.25
p.D1964N	DO229137	NKTL	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.3056
p.D1964N	DO229137	NKTL	ICGC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.25
p.D1964N	DO229137	NKTL	ICGC	PPSY	ITCH	1972:1975	Mutation rewiring degron network	0.1111
p.D1964N	DO229446	SKCA	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.3056
p.D1964N	DO229446	SKCA	ICGC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.25
p.D1964N	DO229446	SKCA	ICGC	PPSY	ITCH	1972:1975	Mutation rewiring degron network	0.1111
p.T1969A	DO232761	PBCA	ICGC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation altering degron motif	0.6028
p.T1969A	DO232761	PBCA	ICGC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation altering degron motif	0.7139
p.E1984K	DO229462	SKCA	ICGC	PPSY	ITCH	1972:1975	Mutation rewiring degron network	0.0833
p.M1128V	SIDM00572	Gastric Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.M1128V	ACH-000911	Gastric Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.M1128V	NUGC-3	stomach	COSMIC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.S1131N	SIDM00193	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.S1131N	ACH-000991	Colon/Colorectal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.S1131N	SNU-81	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.S1977N	SIDM00596	Endometrial Carcinoma	GDSC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.1389
p.S1977N	SIDM00596	Endometrial Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1667
p.S1977N	SIDM00596	Endometrial Carcinoma	GDSC	PPSY	ITCH	1972:1975	Mutation rewiring degron network	0.2778
p.S1977N	ACH-001517	Endometrial/Uterine Cancer	CCLE	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.1389
p.S1977N	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1667
p.S1977N	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	1972:1975	Mutation rewiring degron network	0.2778
p.S1977N	HEC-1	endometrium	COSMIC	MTPSTT	DEG_SCF_FBW7_1	1965:1970	Mutation rewiring degron network	0.1389
p.S1977N	HEC-1	endometrium	COSMIC	PSTTS	DEG_SPOP_SBC_1	1967:1971	Mutation rewiring degron network	0.1667
p.S1977N	HEC-1	endometrium	COSMIC	PPSY	ITCH	1972:1975	Mutation rewiring degron network	0.2778
p.S1892F	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.S1892F	ACH-000873	Esophageal Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.S1892F	KYSE-270	oesophagus	COSMIC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation rewiring degron network	0.25
p.Y1932C	SIDM00217	Colorectal Carcinoma	GDSC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.1389
p.Y1932C	ACH-000999	Colon/Colorectal Cancer	CCLE	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.1389
p.Y1932C	SNU-1040	large intestine	COSMIC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation rewiring degron network	0.1389
p.D473Y	SIDM00534	Colorectal Carcinoma	GDSC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1389
p.D473Y	ACH-000986	Colon/Colorectal Cancer	CCLE	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1389
p.D473Y	HT-115	large intestine	COSMIC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1389
p.Y1893N	SIDM00528	Breast Carcinoma	GDSC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation blocking phosphorylation signal	0.7222
p.Y1893N	ACH-000934	Breast Cancer	CCLE	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation blocking phosphorylation signal	0.7222
p.Y1893N	MDA-MB-361	breast	COSMIC	PITTT	DEG_SPOP_SBC_1	1895:1899	Mutation blocking phosphorylation signal	0.7222
p.P1944T	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation altering degron motif	0.7031
p.P1944T	ACH-000869	Lung Cancer	CCLE	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation altering degron motif	0.7031
p.P1944T	NCI-H1568	lung	COSMIC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	1939:1946	Mutation altering degron motif	0.7031
p.K1128Q	GMS-10	central nervous system	COSMIC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.0833
p.S1144G	HPAC	pancreas	COSMIC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.25
p.S1139T	A427	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation altering degron motif	0.6005
p.R488Q	FADU	upper aerodigestive tract	COSMIC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.25
p.R488Q	KM12	large intestine	COSMIC	IGVFSE	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.25
p.A1131S	SF126	central nervous system	COSMIC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1667
p.V1130L	MRK-nu-1	breast	COSMIC	ATSSS	DEG_SPOP_SBC_1	1137:1141	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN2A

UniProt ID: Q99250

Entrez ID: 6326

Protein name: Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCN2A in