DegronMD

Uniprot ID: Q99250

Source protein: Sodium channel protein type 2 subunit alpha

Source gene: SCN2A

Class: LIG_APCC_ABBA_1

Location: 480:485

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8176

ASA_SCORE: 73.9167

COIL: 0.7382

CONS_SCORE: 0.2812

DSS_SCORE: 0.394

HELIX: 0.1453

FCONS_SCORE: 0.9725

RIG_SCORE: 0.6568

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G479W	TCGA-05-4410	LUAD	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.3056
p.G479W	DO25426	LUAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.3056
p.G481E	TCGA-20-1684	OV	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.6087
p.G481E	TCGA-ER-A193	SKCM	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.6087
p.G481E	DO32009	OV	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.6087
p.G481E	DO47368	SKCM	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.6087
p.S494I	TCGA-77-A5G7	LUSC	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.0833
p.S494I	DO50098	LUSC	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.0833
p.S486I	TCGA-85-8071	LUSC	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.3056
p.S486I	DO26755	LUSC	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.3056
p.D473N	TCGA-A5-A0G2	UCEC	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.1389
p.D473N	DO234230	ESAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.1389
p.D473N	DO41235	UCEC	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.1389
p.S487F	TCGA-BR-7959	STAD	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.2778
p.S487F	DO38408	STAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.2778
p.L493V	TCGA-D7-6527	STAD	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.1111
p.L493V	DO38635	STAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.1111
p.G481R	TCGA-EE-A2GO	SKCM	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.6457
p.G481R	DO37823	SKCM	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.6457
p.S484L	TCGA-FR-A8YC	SKCM	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.6556
p.S484L	DO50301	SKCM	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.6556
p.K492T	TCGA-HU-A4H2	STAD	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.25
p.K492T	DO47825	STAD	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.25
p.R472G	TCGA-W2-A7HH	PCPG	TCGA	IGVFSE	LIG_APCC_ABBA_1	0.1111
p.V482G	DO233176	GACA	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.7532
p.G478V	DO229038	LICA	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.2778
p.G478C	DO229041	LICA	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.2778
p.G476C	DO229045	LICA	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.2222
p.I480K	DO230934	LUSC	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.7531
p.I480K	DO224581	LUSC	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.7531
p.S488L	DO222696	MELA	ICGC	IGVFSE	LIG_APCC_ABBA_1	0.25
p.D473Y	SIDM00534	Colorectal Carcinoma	GDSC	IGVFSE	LIG_APCC_ABBA_1	0.1389
p.D473Y	ACH-000986	Colon/Colorectal Cancer	CCLE	IGVFSE	LIG_APCC_ABBA_1	0.1389
p.D473Y	HT-115	large_intestine	COSMIC	IGVFSE	LIG_APCC_ABBA_1	0.1389
p.R488Q	FADU	upper_aerodigestive_tract	COSMIC	IGVFSE	LIG_APCC_ABBA_1	0.25
p.R488Q	KM12	large_intestine	COSMIC	IGVFSE	LIG_APCC_ABBA_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IGVFSE

Degron related mutations and impact score

Drug responses associated with SCN2A mutations

All proteins holding degron of IGVFSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99250	Sodium channel protein type 2 subunit alpha	LIG_APCC_ABBA_1	480:485	IGVFSE	APC,CDC20,FZR1	0.8176	More...