DegronMD

Uniprot ID: Q99250

Source protein: Sodium channel protein type 2 subunit alpha

Source gene: SCN2A

Class: DEG_SCF_SKP2-CKS1_1

Location: 1939:1946

E3 ligase: SKP2,CSK1

DEGRON score: 0.9487

ASA_SCORE: 86.7375

COIL: 0.8735

CONS_SCORE: 0.276

DSS_SCORE: 0.4771

HELIX: 0.0629

FCONS_SCORE: 1.0152

RIG_SCORE: 0.7229

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1952N	TCGA-55-8089	LUAD	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.1667
p.D1952N	DO23690	LUAD	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.1667
p.D1935Y	TCGA-86-6851	LUAD	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D1935Y	DO23798	LUAD	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.2222
p.T1949N	TCGA-AP-A0LM	UCEC	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.25
p.T1949N	DO43306	UCEC	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.25
p.E1956D	TCGA-B5-A11E	UCEC	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E1956D	DO41644	UCEC	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G1942E	TCGA-EE-A3JD	SKCM	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.6087
p.G1942E	DO50299	SKCM	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.6087
p.D1935E	TCGA-FS-A4FD	SKCM	TCGA	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D1935E	DO37699	SKCM	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.2222
p.I1945M	DO234197	ESAD	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.6507
p.T1943K	DO50780	LIRI	ICGC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.7306
p.Y1932C	SIDM00217	Colorectal Carcinoma	GDSC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.1389
p.Y1932C	ACH-000999	Colon/Colorectal Cancer	CCLE	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.1389
p.Y1932C	SNU-1040	large_intestine	COSMIC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P1944T	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P1944T	ACH-000869	Lung Cancer	CCLE	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P1944T	NCI-H1568	lung	COSMIC	ECDGTPIK	DEG_SCF_SKP2-CKS1_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SCF_SKP2-CKS1_1	1939:1946	ECDGTPIK	SKP2,CSK1	0.9487	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons