DegronMD

Uniprot ID: Q99250

Source protein: Sodium channel protein type 2 subunit alpha

Source gene: SCN2A

Class: DEG_SCF_FBW7_1

Location: 1965:1970

E3 ligase: FBXW7

DEGRON score: 0.7577

ASA_SCORE: 100.7667

COIL: 0.9697

CONS_SCORE: 0.2876

DSS_SCORE: 0.7365

HELIX: 0.0113

FCONS_SCORE: 1.021

RIG_SCORE: 0.5758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1960A	TCGA-60-2723	LUSC	TCGA	MTPSTT	DEG_SCF_FBW7_1	0.1944
p.P1960A	DO27152	LUSC	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.1944
p.E1956D	TCGA-B5-A11E	UCEC	TCGA	MTPSTT	DEG_SCF_FBW7_1	0.0833
p.E1956D	DO41644	UCEC	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.0833
p.T1966M	TCGA-BR-4280	STAD	TCGA	MTPSTT	DEG_SCF_FBW7_1	0.7423
p.T1966M	DO38663	STAD	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.7423
p.E1961D	TCGA-CA-6718	COAD	TCGA	MTPSTT	DEG_SCF_FBW7_1	0.2222
p.E1961D	TCGA-F5-6814	READ	TCGA	MTPSTT	DEG_SCF_FBW7_1	0.2222
p.E1961D	DO7801	COAD	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.2222
p.E1961D	DO36556	READ	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.2222
p.V1978L	DO229027	LICA	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.1111
p.D1976Y	DO229008	LICA	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.1667
p.D1964N	DO229137	NKTL	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.3056
p.D1964N	DO229446	SKCA	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.3056
p.T1969A	DO232761	PBCA	ICGC	MTPSTT	DEG_SCF_FBW7_1	0.6028
p.S1977N	SIDM00596	Endometrial Carcinoma	GDSC	MTPSTT	DEG_SCF_FBW7_1	0.1389
p.S1977N	ACH-001517	Endometrial/Uterine Cancer	CCLE	MTPSTT	DEG_SCF_FBW7_1	0.1389
p.S1977N	HEC-1	endometrium	COSMIC	MTPSTT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SCF_FBW7_1	1965:1970	MTPSTT	FBXW7	0.7577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons