DegronMD

Uniprot ID: Q684P5

Source protein: Rap1 GTPase-activating protein 2

Source gene: RAP1GAP2

Class: DEG_SPOP_SBC_1

Location: 664:668

E3 ligase: SPOP

DEGRON score: 0.998

ASA_SCORE: 78.46

COIL: 0.9324

CONS_SCORE: 0.3925

DSS_SCORE: 0.666

HELIX: 0.0276

FCONS_SCORE: 1.0234

RIG_SCORE: 0.5992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P664L	TCGA-AD-6895	COAD	TCGA	PSTTS	DEG_SPOP_SBC_1	0.7582
p.P664L	DO8938	COAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7582
p.P664L	SIDM00944	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.7582
p.P664L	ACH-000249	Colon/Colorectal Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.7582
p.S659N	TCGA-CC-5259	LIHC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.1944
p.S659N	DO44886	LIHC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1944
p.M654I	DO229034	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.0556
p.V676F	DO33264	PACA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1111
p.T666M	DO38404	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7423
p.M666V	LU-134-A	lung	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with RAP1GAP2 mutations

All proteins holding degron of PSTTS