DegronMD - Q684P5(RAP1GAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K400N	TCGA-55-8506	LUAD	TCGA	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation substituting flanking lysine	0.3056
p.K400N	DO45390	LUAD	ICGC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation substituting flanking lysine	0.3056
p.E395D	TCGA-A5-A0G2	UCEC	TCGA	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation altering degron motif	0.6758
p.E395D	TCGA-AX-A0J0	UCEC	TCGA	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation altering degron motif	0.6758
p.E395D	DO41235	UCEC	ICGC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation altering degron motif	0.6758
p.E395D	DO41133	UCEC	ICGC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation altering degron motif	0.6758
p.P664L	TCGA-AD-6895	COAD	TCGA	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.7582
p.P664L	DO8938	COAD	ICGC	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.7582
p.P664L	SIDM00944	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.7582
p.P664L	ACH-000249	Colon/Colorectal Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.7582
p.V389A	TCGA-B5-A0JR	UCEC	TCGA	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation altering degron motif	0.6936
p.V389A	DO41791	UCEC	ICGC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation altering degron motif	0.6936
p.S659N	TCGA-CC-5259	LIHC	TCGA	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.1944
p.S659N	DO44886	LIHC	ICGC	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.1944
p.Y384H	TCGA-KL-8340	KICH	TCGA	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation rewiring degron network	0.1944
p.Y384H	DO220348	KICH	ICGC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation rewiring degron network	0.1944
p.M654I	DO229034	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.0556
p.E390D	DO229045	LICA	ICGC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation altering degron motif	0.5647
p.G393D	DO222843	MELA	ICGC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation altering degron motif	0.6087
p.V676F	DO33264	PACA	ICGC	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.1111
p.T666M	DO38404	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.7423
p.V386L	SIDM01050	Biliary Tract Carcinoma	GDSC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation rewiring degron network	0.25
p.V386L	ACH-001494	Bile Duct Cancer	CCLE	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation rewiring degron network	0.25
p.V386L	EGI-1	biliary tract	COSMIC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation rewiring degron network	0.25
p.M666V	LU-134-A	lung	COSMIC	PSTTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.7208
p.P381S	HEC-1	endometrium	COSMIC	VETPGTE	DEG_SCF_FBW7_2	389:395	Mutation rewiring degron network	0.1111

Kaplan plot for RAP1GAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAP1GAP2

UniProt ID: Q684P5

Entrez ID: 23108

Protein name: Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAP1GAP2 in