DegronMD

Uniprot ID: Q684P5

Source protein: Rap1 GTPase-activating protein 2

Source gene: RAP1GAP2

Class: DEG_SCF_FBW7_2

Location: 389:395

E3 ligase: FBXW7

DEGRON score: 0.544

ASA_SCORE: 74.2143

COIL: 0.7191

CONS_SCORE: 0.4034

DSS_SCORE: 0.2287

HELIX: 0.0137

FCONS_SCORE: 0.6074

RIG_SCORE: 0.7222

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K400N	TCGA-55-8506	LUAD	TCGA	VETPGTE	DEG_SCF_FBW7_2	0.3056
p.K400N	DO45390	LUAD	ICGC	VETPGTE	DEG_SCF_FBW7_2	0.3056
p.E395D	TCGA-A5-A0G2	UCEC	TCGA	VETPGTE	DEG_SCF_FBW7_2	0.6758
p.E395D	TCGA-AX-A0J0	UCEC	TCGA	VETPGTE	DEG_SCF_FBW7_2	0.6758
p.E395D	DO41235	UCEC	ICGC	VETPGTE	DEG_SCF_FBW7_2	0.6758
p.E395D	DO41133	UCEC	ICGC	VETPGTE	DEG_SCF_FBW7_2	0.6758
p.V389A	TCGA-B5-A0JR	UCEC	TCGA	VETPGTE	DEG_SCF_FBW7_2	0.6936
p.V389A	DO41791	UCEC	ICGC	VETPGTE	DEG_SCF_FBW7_2	0.6936
p.Y384H	TCGA-KL-8340	KICH	TCGA	VETPGTE	DEG_SCF_FBW7_2	0.1944
p.Y384H	DO220348	KICH	ICGC	VETPGTE	DEG_SCF_FBW7_2	0.1944
p.E390D	DO229045	LICA	ICGC	VETPGTE	DEG_SCF_FBW7_2	0.5647
p.G393D	DO222843	MELA	ICGC	VETPGTE	DEG_SCF_FBW7_2	0.6087
p.V386L	SIDM01050	Biliary Tract Carcinoma	GDSC	VETPGTE	DEG_SCF_FBW7_2	0.25
p.V386L	ACH-001494	Bile Duct Cancer	CCLE	VETPGTE	DEG_SCF_FBW7_2	0.25
p.V386L	EGI-1	biliary_tract	COSMIC	VETPGTE	DEG_SCF_FBW7_2	0.25
p.P381S	HEC-1	endometrium	COSMIC	VETPGTE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q684P5	Rap1 GTPase-activating protein 2	DEG_SCF_FBW7_2	389:395	VETPGTE	FBXW7	0.544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons