DegronMD - Q4G112(HSF5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P262L	TCGA-05-4410	LUAD	TCGA	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.0833
p.P262L	TCGA-75-6214	LUAD	TCGA	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.0833
p.P262L	DO25426	LUAD	ICGC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.0833
p.P262L	DO24830	LUAD	ICGC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.0833
p.S427I	TCGA-05-4427	LUAD	TCGA	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.2222
p.S427I	DO23666	LUAD	ICGC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.2222
p.V278A	TCGA-2W-A8YY	CESC	TCGA	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.25
p.V278A	DO223732	CESC	ICGC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.25
p.V276A	TCGA-85-6798	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.3056
p.V276A	DO27295	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.3056
p.V435E	TCGA-85-A511	LUSC	TCGA	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.6582
p.V435E	DO45509	LUSC	ICGC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.6582
p.S275Y	TCGA-AA-3977	COAD	TCGA	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.712
p.S275Y	DO8730	COAD	ICGC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.712
p.S441Y	TCGA-AA-A010	COAD	TCGA	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.2222
p.A423P	TCGA-AP-A0LM	UCEC	TCGA	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1111
p.A423P	DO43306	UCEC	ICGC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1111
p.N371K	TCGA-B5-A1MR	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0833
p.N371K	DO41758	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0833
p.S272N	TCGA-B5-A3FC	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.5958
p.S272N	DO41871	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation altering degron motif	0.5958
p.P354S	TCGA-BR-6452	STAD	TCGA	PCSTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.2222
p.P354S	DO38404	STAD	ICGC	PCSTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.2222
p.F442V	TCGA-EO-A22R	UCEC	TCGA	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1944
p.F442V	DO42713	UCEC	ICGC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1944
p.P358S	TCGA-VQ-A94R	STAD	TCGA	PCSTT	DEG_SPOP_SBC_1	358:362	Mutation altering degron motif	0.6752
p.P358S	DO222372	STAD	ICGC	PCSTT	DEG_SPOP_SBC_1	358:362	Mutation altering degron motif	0.6752
p.G436V	DO6519	CLLE	ICGC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.6421
p.L429M	DO233178	GACA	ICGC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.2778
p.Q280K	DO229022	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.1944
p.T446K	DO51046	PRAD	ICGC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.0833
p.M440T	SIDM00845	Burkitt's Lymphoma	GDSC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.25
p.M440T	SIDM00461	Acute Myeloid Leukemia	GDSC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.25
p.M440T	ACH-000786	Lymphoma	CCLE	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.25
p.Q279R	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2222
p.Q279R	ACH-000452	Esophageal Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2222
p.Q279R	TE-8	oesophagus	COSMIC	PSTTS	DEG_SPOP_SBC_1	271:275	Mutation rewiring degron network	0.2222
p.T446R	SIDM01611	Endometrial Carcinoma	GDSC	PLTPVGS	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HSF5

UniProt ID: Q4G112

Entrez ID: 124535

Protein name: Heat shock factor protein 5 (HSF 5) (Heat shock transcription factor 5) (HSTF 5)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HSF5 in