DegronMD

Uniprot ID: Q4G112

Source protein: Heat shock factor protein 5

Source gene: HSF5

Class: DEG_SCF_FBW7_1

Location: 431:437

E3 ligase: FBXW7

DEGRON score: 0.8085

ASA_SCORE: 63.5714

COIL: 0.8184

CONS_SCORE: 0.5056

DSS_SCORE: 0.3514

HELIX: 0.0681

FCONS_SCORE: 0.9749

RIG_SCORE: 0.6983

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S427I	TCGA-05-4427	LUAD	TCGA	PLTPVGS	DEG_SCF_FBW7_1	0.2222
p.S427I	DO23666	LUAD	ICGC	PLTPVGS	DEG_SCF_FBW7_1	0.2222
p.V435E	TCGA-85-A511	LUSC	TCGA	PLTPVGS	DEG_SCF_FBW7_1	0.6582
p.V435E	DO45509	LUSC	ICGC	PLTPVGS	DEG_SCF_FBW7_1	0.6582
p.S441Y	TCGA-AA-A010	COAD	TCGA	PLTPVGS	DEG_SCF_FBW7_1	0.2222
p.A423P	TCGA-AP-A0LM	UCEC	TCGA	PLTPVGS	DEG_SCF_FBW7_1	0.1111
p.A423P	DO43306	UCEC	ICGC	PLTPVGS	DEG_SCF_FBW7_1	0.1111
p.F442V	TCGA-EO-A22R	UCEC	TCGA	PLTPVGS	DEG_SCF_FBW7_1	0.1944
p.F442V	DO42713	UCEC	ICGC	PLTPVGS	DEG_SCF_FBW7_1	0.1944
p.G436V	DO6519	CLLE	ICGC	PLTPVGS	DEG_SCF_FBW7_1	0.6421
p.L429M	DO233178	GACA	ICGC	PLTPVGS	DEG_SCF_FBW7_1	0.2778
p.T446K	DO51046	PRAD	ICGC	PLTPVGS	DEG_SCF_FBW7_1	0.0833
p.M440T	SIDM00845	Burkitt's Lymphoma	GDSC	PLTPVGS	DEG_SCF_FBW7_1	0.25
p.M440T	SIDM00461	Acute Myeloid Leukemia	GDSC	PLTPVGS	DEG_SCF_FBW7_1	0.25
p.M440T	ACH-000786	Lymphoma	CCLE	PLTPVGS	DEG_SCF_FBW7_1	0.25
p.T446R	SIDM01611	Endometrial Carcinoma	GDSC	PLTPVGS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G112	Heat shock factor protein 5	DEG_SCF_FBW7_1	431:437	PLTPVGS	FBXW7	0.8085	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons