DegronMD

Uniprot ID: Q4G112

Source protein: Heat shock factor protein 5

Source gene: HSF5

Class: DEG_SPOP_SBC_1

Location: 358:362

E3 ligase: SPOP

DEGRON score: 0.8576

ASA_SCORE: 79.92

COIL: 0.9182

CONS_SCORE: 0.5371

DSS_SCORE: 0.4033

HELIX: 0.0494

FCONS_SCORE: 0.9599

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N371K	TCGA-B5-A1MR	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.0833
p.N371K	DO41758	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.0833
p.P354S	TCGA-BR-6452	STAD	TCGA	PCSTT	DEG_SPOP_SBC_1	0.2222
p.P354S	DO38404	STAD	ICGC	PCSTT	DEG_SPOP_SBC_1	0.2222
p.P358S	TCGA-VQ-A94R	STAD	TCGA	PCSTT	DEG_SPOP_SBC_1	0.6752
p.P358S	DO222372	STAD	ICGC	PCSTT	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	DEG_SPOP_SBC_1	146:150	PCSTT	SPOP	0.9952	More...
Q13639	5-hydroxytryptamine receptor 4	DEG_SPOP_SBC_1	345:349	PCSTT	SPOP	0.8001	More...
Q8NAT2	Tudor domain-containing protein 5	DEG_SPOP_SBC_1	883:887	PCSTT	SPOP	0.9327	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	358:362	PCSTT	SPOP	0.8576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons