DegronMD - Q13639(HTR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G353E	TCGA-DX-AB2E	SARC	TCGA	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2222
p.G353E	DO220073	SARC	ICGC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2222
p.T348P	TCGA-F5-6814	READ	TCGA	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7031
p.T348P	DO36556	READ	ICGC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7031
p.T348P	SIDM00630	Breast Carcinoma	GDSC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7031
p.T348P	ACH-000876	Breast Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7031
p.T348P	MDA-MB-415	breast	COSMIC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7031
p.L340V	TCGA-LP-A4AX	CESC	TCGA	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1944
p.L340V	DO44358	CESC	ICGC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1944
p.S354F	DO220906	MELA	ICGC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation blocking phosphorylation signal	0.6389
p.P345S	DO222409	MELA	ICGC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.6752
p.G353R	DO229502	SKCA	ICGC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.2222
p.L340Q	SIDM00545	Melanoma	GDSC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1944
p.L340Q	ACH-000987	Skin Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1944
p.L340Q	Mewo	skin	COSMIC	PCSTT	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons