DegronMD

Uniprot ID: Q13639

Source protein: 5-hydroxytryptamine receptor 4

Source gene: HTR4

Class: DEG_SPOP_SBC_1

Location: 345:349

E3 ligase: SPOP

DEGRON score: 0.8001

ASA_SCORE: 81.34

COIL: 0.8006

CONS_SCORE: 0.4312

DSS_SCORE: 0.2774

HELIX: 0.021

FCONS_SCORE: 1.0689

RIG_SCORE: 0.7758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G353E	TCGA-DX-AB2E	SARC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.2222
p.G353E	DO220073	SARC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.2222
p.T348P	TCGA-F5-6814	READ	TCGA	PCSTT	DEG_SPOP_SBC_1	0.7031
p.T348P	DO36556	READ	ICGC	PCSTT	DEG_SPOP_SBC_1	0.7031
p.T348P	SIDM00630	Breast Carcinoma	GDSC	PCSTT	DEG_SPOP_SBC_1	0.7031
p.T348P	ACH-000876	Breast Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	0.7031
p.T348P	MDA-MB-415	breast	COSMIC	PCSTT	DEG_SPOP_SBC_1	0.7031
p.L340V	TCGA-LP-A4AX	CESC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.1944
p.L340V	DO44358	CESC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.1944
p.S354F	DO220906	MELA	ICGC	PCSTT	DEG_SPOP_SBC_1	0.6389
p.P345S	DO222409	MELA	ICGC	PCSTT	DEG_SPOP_SBC_1	0.6752
p.G353R	DO229502	SKCA	ICGC	PCSTT	DEG_SPOP_SBC_1	0.2222
p.L340Q	SIDM00545	Melanoma	GDSC	PCSTT	DEG_SPOP_SBC_1	0.1944
p.L340Q	ACH-000987	Skin Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	0.1944
p.L340Q	Mewo	skin	COSMIC	PCSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	DEG_SPOP_SBC_1	146:150	PCSTT	SPOP	0.9952	More...
Q13639	5-hydroxytryptamine receptor 4	DEG_SPOP_SBC_1	345:349	PCSTT	SPOP	0.8001	More...
Q8NAT2	Tudor domain-containing protein 5	DEG_SPOP_SBC_1	883:887	PCSTT	SPOP	0.9327	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	358:362	PCSTT	SPOP	0.8576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons