DegronMD - Q8NAT2(TDRD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S893Y	TCGA-06-5416	GBM	TCGA	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1667
p.S893Y	DO10880	GBM	ICGC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1667
p.N879K	TCGA-77-7463	LUSC	TCGA	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.2222
p.R880G	TCGA-86-8358	LUAD	TCGA	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.25
p.R880G	DO25471	LUAD	ICGC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.25
p.D886N	TCGA-AG-A00Y	READ	TCGA	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.6932
p.D892N	TCGA-AG-A00Y	READ	TCGA	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1944
p.R880M	TCGA-AP-A059	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.25
p.R880M	DO41361	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.25
p.T881I	TCGA-AX-A05Z	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.2778
p.T881I	DO40884	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.2778
p.K883N	TCGA-EO-A22R	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.6918
p.S891T	DO228194	LICA	ICGC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.2222
p.S897F	DO24140	LUAD	ICGC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.0556
p.A893T	DO41752	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1667
p.G889D	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.2778
p.D886Y	SIDM01611	Endometrial Carcinoma	GDSC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7325
p.K895R	ACH-000995	Leukemia	CCLE	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation substituting flanking lysine	0.2222
p.K895R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation substituting flanking lysine	0.2222
p.D890Y	ACH-001061	Colon/Colorectal Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.25
p.S892C	ACH-001459	Colon/Colorectal Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1944

Kaplan plot for TDRD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TDRD5

UniProt ID: Q8NAT2

Entrez ID: 163589

Protein name: Tudor domain-containing protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TDRD5 in