DegronMD

Uniprot ID: Q8NAT2

Source protein: Tudor domain-containing protein 5

Source gene: TDRD5

Class: DEG_SPOP_SBC_1

Location: 883:887

E3 ligase: SPOP

DEGRON score: 0.9327

ASA_SCORE: 88.44

COIL: 0.9316

CONS_SCORE: 0.2072

DSS_SCORE: 0.6075

HELIX: 0.034

FCONS_SCORE: 0.716

RIG_SCORE: 0.6646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S893Y	TCGA-06-5416	GBM	TCGA	PCSTT	DEG_SPOP_SBC_1	0.1667
p.S893Y	DO10880	GBM	ICGC	PCSTT	DEG_SPOP_SBC_1	0.1667
p.N879K	TCGA-77-7463	LUSC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.2222
p.R880G	TCGA-86-8358	LUAD	TCGA	PCSTT	DEG_SPOP_SBC_1	0.25
p.R880G	DO25471	LUAD	ICGC	PCSTT	DEG_SPOP_SBC_1	0.25
p.D886N	TCGA-AG-A00Y	READ	TCGA	PCSTT	DEG_SPOP_SBC_1	0.6932
p.D892N	TCGA-AG-A00Y	READ	TCGA	PCSTT	DEG_SPOP_SBC_1	0.1944
p.R880M	TCGA-AP-A059	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.25
p.R880M	DO41361	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.25
p.T881I	TCGA-AX-A05Z	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.2778
p.T881I	DO40884	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.2778
p.K883N	TCGA-EO-A22R	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.6918
p.S891T	DO228194	LICA	ICGC	PCSTT	DEG_SPOP_SBC_1	0.2222
p.S897F	DO24140	LUAD	ICGC	PCSTT	DEG_SPOP_SBC_1	0.0556
p.A893T	DO41752	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.1667
p.G889D	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PCSTT	DEG_SPOP_SBC_1	0.2778
p.D886Y	SIDM01611	Endometrial Carcinoma	GDSC	PCSTT	DEG_SPOP_SBC_1	0.7325
p.K895R	ACH-000995	Leukemia	CCLE	PCSTT	DEG_SPOP_SBC_1	0.2222
p.K895R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PCSTT	DEG_SPOP_SBC_1	0.2222
p.D890Y	ACH-001061	Colon/Colorectal Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	0.25
p.S892C	ACH-001459	Colon/Colorectal Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	DEG_SPOP_SBC_1	146:150	PCSTT	SPOP	0.9952	More...
Q13639	5-hydroxytryptamine receptor 4	DEG_SPOP_SBC_1	345:349	PCSTT	SPOP	0.8001	More...
Q8NAT2	Tudor domain-containing protein 5	DEG_SPOP_SBC_1	883:887	PCSTT	SPOP	0.9327	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	358:362	PCSTT	SPOP	0.8576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons