DegronMD - Q12824(SMARCB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T149K	TCGA-66-2766	LUSC	TCGA	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7306
p.A125V	TCGA-AJ-A3BG	UCEC	TCGA	PPTY	ITCH	116:119	Mutation rewiring degron network	0.1667
p.Q123H	TCGA-AJ-A5DW	UCEC	TCGA	PPTY	ITCH	116:119	Mutation rewiring degron network	0.2222
p.K126N	TCGA-B5-A11R	UCEC	TCGA	PPTY	ITCH	116:119	Mutation substituting flanking lysine	0.25
p.R155H	TCGA-BR-6452	STAD	TCGA	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.R155H	TCGA-BS-A0UL	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.L142I	TCGA-CJ-6030	KIRC	TCGA	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.2222
p.A109D	TCGA-DU-6392	LGG	TCGA	PPTY	ITCH	116:119	Mutation rewiring degron network	0.1389
p.R158Q	TCGA-EO-A22R	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1111
p.R158Q	TCGA-G4-6320	COAD	TCGA	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1111
p.A125D	TCGA-EY-A2OM	UCEC	TCGA	PPTY	ITCH	116:119	Mutation rewiring degron network	0.1667
p.D159N	TCGA-IR-A3LL	CESC	TCGA	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.D150N	DO44362	CESC	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.6932
p.R149Q	DO8159	COAD	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7329
p.R149Q	DO218693	GACA	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7329
p.R149Q	DO42713	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.7329
p.R146H	DO227987	COCA	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.8244
p.R146H	DO38404	STAD	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.8244
p.R146H	DO41319	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.8244
p.R146H	SIDM01293	Colorectal Carcinoma	GDSC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.8244
p.R149L	DO228898	LICA	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation altering degron motif	0.8428
p.T140K	DO27747	LUSC	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.P124L	DO229494	SKCA	ICGC	PPTY	ITCH	116:119	Mutation blocking ubiquitination signal	0.6389
p.Q114H	DO50075	UCEC	ICGC	PPTY	ITCH	116:119	Mutation rewiring degron network	0.2778
p.A116D	DO43025	UCEC	ICGC	PPTY	ITCH	116:119	Mutation altering degron motif	0.7793
p.K117N	DO43787	UCEC	ICGC	PPTY	ITCH	116:119	Mutation altering degron motif	0.6918
p.P137A	DO41199	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.0833
p.A116V	DO42633	UCEC	ICGC	PPTY	ITCH	116:119	Mutation altering degron motif	0.6936
p.P156S	SIDM00611	Kidney Carcinoma	GDSC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.P156S	KMRC-1	kidney	COSMIC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1667
p.R155Q	ACH-000694	Esophageal Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.R155Q	TE-9	oesophagus	COSMIC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.1944
p.L120R	ACH-001518	Endometrial/Uterine Cancer	CCLE	PPTY	ITCH	116:119	Mutation rewiring degron network	0.3056
p.L145P	ACH-001550	Skin Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.3056
p.L145P	MCC13	skin	COSMIC	PCSTT	DEG_SPOP_SBC_1	146:150	Mutation rewiring degron network	0.3056

Kaplan plot for SMARCB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCB1

UniProt ID: Q12824

Entrez ID: 6598

Protein name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMARCB1 in