DegronMD

Uniprot ID: Q12824

Source protein: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

Source gene: SMARCB1

Class: DEG_SPOP_SBC_1

Location: 146:150

E3 ligase: SPOP

DEGRON score: 0.9952

ASA_SCORE: 68.9

COIL: 0.8628

CONS_SCORE: 0.3109

DSS_SCORE: 0.4717

HELIX: 0.045

FCONS_SCORE: 1.0334

RIG_SCORE: 0.7431

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T149K	TCGA-66-2766	LUSC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.7306
p.R155H	TCGA-BR-6452	STAD	TCGA	PCSTT	DEG_SPOP_SBC_1	0.1944
p.R155H	TCGA-BS-A0UL	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.1944
p.L142I	TCGA-CJ-6030	KIRC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.2222
p.R158Q	TCGA-EO-A22R	UCEC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.1111
p.R158Q	TCGA-G4-6320	COAD	TCGA	PCSTT	DEG_SPOP_SBC_1	0.1111
p.D159N	TCGA-IR-A3LL	CESC	TCGA	PCSTT	DEG_SPOP_SBC_1	0.0833
p.D150N	DO44362	CESC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.6932
p.R149Q	DO8159	COAD	ICGC	PCSTT	DEG_SPOP_SBC_1	0.7329
p.R149Q	DO218693	GACA	ICGC	PCSTT	DEG_SPOP_SBC_1	0.7329
p.R149Q	DO42713	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.7329
p.R146H	DO227987	COCA	ICGC	PCSTT	DEG_SPOP_SBC_1	0.8244
p.R146H	DO38404	STAD	ICGC	PCSTT	DEG_SPOP_SBC_1	0.8244
p.R146H	DO41319	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.8244
p.R146H	SIDM01293	Colorectal Carcinoma	GDSC	PCSTT	DEG_SPOP_SBC_1	0.8244
p.R149L	DO228898	LICA	ICGC	PCSTT	DEG_SPOP_SBC_1	0.8428
p.T140K	DO27747	LUSC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.1667
p.P137A	DO41199	UCEC	ICGC	PCSTT	DEG_SPOP_SBC_1	0.0833
p.P156S	SIDM00611	Kidney Carcinoma	GDSC	PCSTT	DEG_SPOP_SBC_1	0.1667
p.P156S	KMRC-1	kidney	COSMIC	PCSTT	DEG_SPOP_SBC_1	0.1667
p.R155Q	ACH-000694	Esophageal Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	0.1944
p.R155Q	TE-9	oesophagus	COSMIC	PCSTT	DEG_SPOP_SBC_1	0.1944
p.L145P	ACH-001550	Skin Cancer	CCLE	PCSTT	DEG_SPOP_SBC_1	0.3056
p.L145P	MCC13	skin	COSMIC	PCSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	DEG_SPOP_SBC_1	146:150	PCSTT	SPOP	0.9952	More...
Q13639	5-hydroxytryptamine receptor 4	DEG_SPOP_SBC_1	345:349	PCSTT	SPOP	0.8001	More...
Q8NAT2	Tudor domain-containing protein 5	DEG_SPOP_SBC_1	883:887	PCSTT	SPOP	0.9327	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	358:362	PCSTT	SPOP	0.8576	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons