DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 113:117

E3 ligase: SPOP

DEGRON score: 0.9869

ASA_SCORE: 84.66

COIL: 0.9482

CONS_SCORE: 0.4153

DSS_SCORE: 0.6584

HELIX: 0.0288

FCONS_SCORE: 0.9942

RIG_SCORE: 0.6195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T116A	TCGA-60-2719	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	0.7139
p.T116A	DO27453	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	0.7139
p.A119T	TCGA-DK-A2I4	BLCA	TCGA	PSTTS	DEG_SPOP_SBC_1	0.2778
p.A119T	DO465	BLCA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.E111K	TCGA-DU-6392	LGG	TCGA	PSTTS	DEG_SPOP_SBC_1	0.2778
p.E111K	DO22237	LGG	ICGC	PSTTS	DEG_SPOP_SBC_1	0.2778
p.T118N	DO228900	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.T118N	DO228976	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.3056
p.P123Q	DO228976	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1667
p.P105T	DO229045	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	0.1111
p.A106T	SIDM00217	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	0.1389
p.A106T	ACH-000999	Colon/Colorectal Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	0.1389
p.A106T	SNU-1040	large_intestine	COSMIC	PSTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95793	Double-stranded RNA-binding protein Staufen homolog 1	DEG_SPOP_SBC_1	36:40	PSTTS	SPOP	0.9778	More...
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SPOP_SBC_1	39:43	PSTTS	SPOP	0.581	More...
P32238	Cholecystokinin receptor type A	DEG_SPOP_SBC_1	255:259	PSTTS	SPOP	0.709	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	144:148	PSTTS	SPOP	0.9919	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	113:117	PSTTS	SPOP	0.9869	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3686:3690	PSTTS	SPOP	0.7046	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4119:4123	PSTTS	SPOP	0.859	More...
Q04900	Sialomucin core protein 24	DEG_SPOP_SBC_1	132:136	PSTTS	SPOP	0.5053	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	674:678	PSTTS	SPOP	0.9729	More...
Q684P5	Rap1 GTPase-activating protein 2	DEG_SPOP_SBC_1	664:668	PSTTS	SPOP	0.998	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	12:16	PSTTS	SPOP	0.9684	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1196:1200	PSTTS	SPOP	0.9172	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1967:1971	PSTTS	SPOP	0.97	More...
Q9HBB8	Cadherin-related family member 5	DEG_SPOP_SBC_1	491:495	PSTTS	SPOP	0.9709	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	1046:1050	PSTTS	SPOP	0.998	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	800:804	PSTTS	SPOP	0.9364	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1866:1870	PSTTS	SPOP	0.9365	More...
Q4G112	Heat shock factor protein 5	DEG_SPOP_SBC_1	271:275	PSTTS	SPOP	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTTS

Degron related mutations and impact score

Drug responses associated with NUP153 mutations

All proteins holding degron of PSTTS