DegronMD - P29558(RBMS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N46D	TCGA-33-4586	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.25
p.N46D	DO27318	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.25
p.I313M	TCGA-78-7633	LUAD	TCGA	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1389
p.A334T	TCGA-AX-A1CE	UCEC	TCGA	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1111
p.A334T	SIDM00428	Acute Myeloid Leukemia	GDSC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1111
p.A334T	ACH-000294	Leukemia	CCLE	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1111
p.A334T	NB-4	haematopoietic and lymphoid tissue	COSMIC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1111
p.S49N	TCGA-BR-4368	STAD	TCGA	PSTTS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.S49N	DO38715	STAD	ICGC	PSTTS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.K406E	TCGA-DI-A1BU	UCEC	TCGA	NDHSPYTFQP	CBL_PTK	395:404	Mutation rewiring degron network	0.2778
p.G318C	TCGA-EE-A2MN	SKCM	TCGA	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.2778
p.L314I	TCGA-EO-A3B0	UCEC	TCGA	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1667
p.I312M	DO2401	BRCA	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1111
p.T388M	DO223732	CESC	ICGC	NDHSPYTFQP	CBL_PTK	395:404	Mutation rewiring degron network	0.1389
p.T388M	DO47933	STAD	ICGC	NDHSPYTFQP	CBL_PTK	395:404	Mutation rewiring degron network	0.1389
p.T388M	DO42600	UCEC	ICGC	NDHSPYTFQP	CBL_PTK	395:404	Mutation rewiring degron network	0.1389
p.E394K	DO9498	COAD	ICGC	NDHSPYTFQP	CBL_PTK	395:404	Mutation rewiring degron network	0.3056
p.P33S	DO233936	GACA	ICGC	PSTTS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.Q321K	DO228976	LICA	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation altering degron motif	0.6944
p.A390E	DO229022	LICA	ICGC	NDHSPYTFQP	CBL_PTK	395:404	Mutation rewiring degron network	0.1944
p.A311D	DO229045	LICA	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.0833
p.T335N	DO229060	LICA	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.0833
p.I326M	DO24359	LUAD	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation altering degron motif	0.7618
p.S310C	DO26898	LUSC	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.0556
p.P39S	DO232761	PBCA	ICGC	PSTTS	DEG_SPOP_SBC_1	39:43	Mutation altering degron motif	0.6752
p.P322S	DO51407	PRAD	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation altering degron motif	0.6752
p.G331C	DO37423	SKCM	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1944
p.A390V	DO38192	STAD	ICGC	NDHSPYTFQP	CBL_PTK	395:404	Mutation rewiring degron network	0.1944
p.L327I	DO219773	UCEC	ICGC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.3056
p.S38C	SIDM01097	Other Solid Cancers	GDSC	PSTTS	DEG_SPOP_SBC_1	39:43	Mutation blocking phosphorylation signal	0.75
p.S330P	SIDM00199	Chondrosarcoma	GDSC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.2222
p.S330P	ACH-002099	Bone Cancer	CCLE	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.2222
p.S330P	CS1	bone	COSMIC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.2222
p.A314T	NB-4	haematopoietic and lymphoid tissue	COSMIC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.1667
p.T323M	SNU-1040	large intestine	COSMIC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation altering degron motif	0.7423
p.S325G	COR-L23	lung	COSMIC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation altering degron motif	0.6993
p.S310P	CS1	bone	COSMIC	VLTPSME	DEG_SCF_FBW7_2	320:326	Mutation rewiring degron network	0.0556

Kaplan plot for RBMS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBMS1

UniProt ID: P29558

Entrez ID: 5937

Protein name: RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBMS1 in