DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NDHSPYTFQP
Uniprot ID:
P29558
Source protein:
RNA-binding motif, single-stranded-interacting protein 1
Source gene:
RBMS1
Class:
CBL_PTK
Location:
395:404
E3 ligase:
CBL
DEGRON score:
0.9963
ASA_SCORE:
103.99
COIL:
0.939
CONS_SCORE:
0.4875
DSS_SCORE:
0.7898
HELIX:
0.0464
FCONS_SCORE:
1.0069
RIG_SCORE:
0.6864
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K406E
TCGA-DI-A1BU
UCEC
TCGA
NDHSPYTFQP
CBL_PTK
0.2778
p.T388M
DO223732
CESC
ICGC
NDHSPYTFQP
CBL_PTK
0.1389
p.T388M
DO47933
STAD
ICGC
NDHSPYTFQP
CBL_PTK
0.1389
p.T388M
DO42600
UCEC
ICGC
NDHSPYTFQP
CBL_PTK
0.1389
p.E394K
DO9498
COAD
ICGC
NDHSPYTFQP
CBL_PTK
0.3056
p.A390E
DO229022
LICA
ICGC
NDHSPYTFQP
CBL_PTK
0.1944
p.A390V
DO38192
STAD
ICGC
NDHSPYTFQP
CBL_PTK
0.1944
Drug responses associated with RBMS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NDHSPYTFQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P29558
RNA-binding motif, single-stranded-interacting protein 1
CBL_PTK
395:404
NDHSPYTFQP
CBL
0.9963
More...
