DegronMD

Uniprot ID: P29558

Source protein: RNA-binding motif, single-stranded-interacting protein 1

Source gene: RBMS1

Class: DEG_SCF_FBW7_2

Location: 320:326

E3 ligase: FBXW7

DEGRON score: 0.9776

ASA_SCORE: 80.7

COIL: 0.8529

CONS_SCORE: 0.5103

DSS_SCORE: 0.4455

HELIX: 0.0841

FCONS_SCORE: 1.1119

RIG_SCORE: 0.687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I313M	TCGA-78-7633	LUAD	TCGA	VLTPSME	DEG_SCF_FBW7_2	0.1389
p.A334T	TCGA-AX-A1CE	UCEC	TCGA	VLTPSME	DEG_SCF_FBW7_2	0.1111
p.A334T	SIDM00428	Acute Myeloid Leukemia	GDSC	VLTPSME	DEG_SCF_FBW7_2	0.1111
p.A334T	ACH-000294	Leukemia	CCLE	VLTPSME	DEG_SCF_FBW7_2	0.1111
p.A334T	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	VLTPSME	DEG_SCF_FBW7_2	0.1111
p.G318C	TCGA-EE-A2MN	SKCM	TCGA	VLTPSME	DEG_SCF_FBW7_2	0.2778
p.L314I	TCGA-EO-A3B0	UCEC	TCGA	VLTPSME	DEG_SCF_FBW7_2	0.1667
p.I312M	DO2401	BRCA	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.1111
p.Q321K	DO228976	LICA	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.6944
p.A311D	DO229045	LICA	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.0833
p.T335N	DO229060	LICA	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.0833
p.I326M	DO24359	LUAD	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.7618
p.S310C	DO26898	LUSC	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.0556
p.P322S	DO51407	PRAD	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.6752
p.G331C	DO37423	SKCM	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.1944
p.L327I	DO219773	UCEC	ICGC	VLTPSME	DEG_SCF_FBW7_2	0.3056
p.S330P	SIDM00199	Chondrosarcoma	GDSC	VLTPSME	DEG_SCF_FBW7_2	0.2222
p.S330P	ACH-002099	Bone Cancer	CCLE	VLTPSME	DEG_SCF_FBW7_2	0.2222
p.S330P	CS1	bone	COSMIC	VLTPSME	DEG_SCF_FBW7_2	0.2222
p.A314T	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	VLTPSME	DEG_SCF_FBW7_2	0.1667
p.T323M	SNU-1040	large_intestine	COSMIC	VLTPSME	DEG_SCF_FBW7_2	0.7423
p.S325G	COR-L23	lung	COSMIC	VLTPSME	DEG_SCF_FBW7_2	0.6993
p.S310P	CS1	bone	COSMIC	VLTPSME	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P29558	RNA-binding motif, single-stranded-interacting protein 1	DEG_SCF_FBW7_2	320:326	VLTPSME	FBXW7	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons