DegronMD - Q9NZP6(NPAP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V198L	TCGA-05-4417	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0833
p.V198L	DO23570	LUAD	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0833
p.P509H	TCGA-17-Z028	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.P509H	TCGA-17-Z028	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.P509H	TCGA-AX-A2HD	UCEC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.P509H	TCGA-AX-A2HD	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.P509H	DO42608	UCEC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.P509H	DO42608	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.D197Y	TCGA-17-Z031	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.S809I	TCGA-17-Z045	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.R513T	TCGA-17-Z056	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0556
p.R513T	TCGA-17-Z056	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.S689L	TCGA-18-3409	LUSC	TCGA	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.0833
p.S689L	DO26444	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.0833
p.G183V	TCGA-21-5786	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.G183V	DO26830	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.V488I	TCGA-22-4594	LUSC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.V488I	TCGA-AG-A015	READ	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.V488I	TCGA-AG-A01Y	READ	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.V488I	DO27476	LUSC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.V488I	DO37396	READ	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.F507I	TCGA-29-2434	OV	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.2222
p.F507I	TCGA-29-2434	OV	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.25
p.F507I	DO31360	OV	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.2222
p.F507I	DO31360	OV	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.25
p.S495Y	TCGA-2F-A9KO	BLCA	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.2778
p.S495Y	TCGA-2F-A9KO	BLCA	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.S495Y	DO51859	BLCA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.2778
p.S495Y	DO51859	BLCA	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1944
p.R513K	TCGA-3N-A9WC	SKCM	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0556
p.R513K	TCGA-3N-A9WC	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.R513K	DO51234	SKCM	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0556
p.R513K	DO51234	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.S887F	TCGA-3N-A9WC	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	TCGA-ER-A195	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	TCGA-FR-A8YC	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	TCGA-WE-A8K5	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	DO50301	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	DO47712	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	DO51282	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	DO51234	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	SIDM00007	Other Solid Cancers	GDSC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	ACH-001550	Skin Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.S887F	MCC13	skin	COSMIC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7982
p.G489E	TCGA-44-A479	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1111
p.G489E	DO23633	LUAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1111
p.S804Y	TCGA-49-AARE	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.712
p.S804Y	DO218922	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.712
p.P674A	TCGA-50-5946	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.P674A	DO24556	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.A813S	TCGA-55-7725	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1111
p.A813S	DO24636	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1111
p.G193V	TCGA-55-7994	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.G193V	DO45311	LUAD	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.T803S	TCGA-56-8622	LUSC	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.6005
p.T803S	DO45449	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.6005
p.L439M	TCGA-58-A46N	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2222
p.L439M	DO45460	LUSC	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2222
p.L439M	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2222
p.L439M	ACH-000951	Lung Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2222
p.L439M	NCI-H2342	lung	COSMIC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2222
p.V682L	TCGA-64-5815	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.V682L	DO23578	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.L180H	TCGA-66-2759	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.L180H	TCGA-VQ-A8PH	STAD	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.L180H	DO27326	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.L180H	DO222349	STAD	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.A1057G	TCGA-66-2791	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1389
p.A1057G	DO26435	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1389
p.A810D	TCGA-69-7979	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1944
p.A810D	DO23874	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1944
p.V488L	TCGA-73-A9RS	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.V488L	DO51193	LUAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.E514V	TCGA-86-8281	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.E514V	DO26318	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.S684C	TCGA-91-6830	LUAD	TCGA	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2222
p.S684C	DO25867	LUAD	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2222
p.S182R	TCGA-92-7340	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.S182R	DO26775	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.Q1040K	TCGA-96-7544	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1389
p.Q1040K	TCGA-96-7544	LUSC	TCGA	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.Q1040K	DO26425	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1389
p.Q1040K	DO26425	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1667
p.G183R	TCGA-98-A53A	LUSC	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.G183R	TCGA-CS-5395	LGG	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.G183R	DO22356	LGG	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.G183R	DO219178	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.G183R	SIDM00879	Breast Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.G183R	SIDM01686	Chronic Myelogenous Leukemia	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.E175K	TCGA-A5-A2K5	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.E175K	DO41379	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S1019R	TCGA-A6-4107	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.0556
p.S1019R	DO10566	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.0556
p.T457P	TCGA-AA-A00N	COAD	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.0556
p.T457P	DO9876	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.0556
p.A491V	TCGA-AA-A01Z	COAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491V	TCGA-AA-A01Z	COAD	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491V	DO8392	COAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491V	DO8392	COAD	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.S794I	TCGA-AJ-A5DW	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1389
p.S794I	DO50075	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1389
p.T680I	TCGA-AX-A2HC	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7078
p.T680I	DO41572	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7078
p.K449N	TCGA-AZ-4315	COAD	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2778
p.K449N	DO8842	COAD	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.2778
p.L437I	TCGA-BA-4076	HNSC	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.L437I	DO14502	HNSC	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.P500R	TCGA-BB-A5HY	HNSC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation altering degron motif	0.7512
p.P500R	TCGA-BB-A5HY	HNSC	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7512
p.P500R	DO218979	HNSC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation altering degron motif	0.7512
p.P500R	DO218979	HNSC	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7512
p.M1024T	TCGA-BC-A10T	LIHC	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1944
p.M1024T	DO22944	LIHC	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1944
p.A433V	TCGA-BF-AAOX	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.0556
p.A433V	DO223907	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.0556
p.F1022L	TCGA-BG-A222	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1389
p.F1022L	DO42977	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1389
p.L493H	TCGA-BR-4184	STAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.2222
p.L493H	TCGA-BR-4184	STAD	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.L493H	DO38328	STAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.2222
p.L493H	DO38328	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.P501R	TCGA-BR-A4QI	STAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation altering degron motif	0.6401
p.P501R	TCGA-BR-A4QI	STAD	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.6401
p.P501R	DO38523	STAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation altering degron motif	0.6401
p.P501R	DO38523	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.6401
p.S1047N	TCGA-BS-A0UF	UCEC	TCGA	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.5958
p.S1047N	DO41488	UCEC	ICGC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation altering degron motif	0.5958
p.P436T	TCGA-CN-4739	HNSC	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1389
p.P436T	DO14478	HNSC	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1389
p.Q1042H	TCGA-CQ-5334	HNSC	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.0833
p.Q1042H	TCGA-CQ-5334	HNSC	TCGA	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.Q1042H	DO16053	HNSC	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.0833
p.Q1042H	DO16053	HNSC	ICGC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.Q1042H	SIDM01318	Hepatocellular Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.0833
p.Q1042H	SIDM01318	Hepatocellular Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2222
p.P883T	TCGA-CR-7388	HNSC	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7031
p.P883T	DO14284	HNSC	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7031
p.D496Y	TCGA-CV-7245	HNSC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.3056
p.D496Y	TCGA-CV-7245	HNSC	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.D496Y	DO14322	HNSC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.3056
p.D496Y	DO14322	HNSC	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.P436L	TCGA-D3-A3ML	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1389
p.P436L	DO47413	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1389
p.P800S	TCGA-D3-A8GL	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.3056
p.P800S	DO50287	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.3056
p.S191A	TCGA-D5-6924	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.S191A	DO7922	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.T447P	TCGA-D6-6516	HNSC	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.7031
p.T447P	DO15623	HNSC	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.7031
p.L444F	TCGA-D9-A1JW	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.587
p.L444F	DO37786	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.587
p.P796S	TCGA-DA-A1HV	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1944
p.P796S	DO37659	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1944
p.L180P	TCGA-DD-A3A9	LIHC	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.L180P	DO44888	LIHC	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1944
p.T512A	TCGA-DU-6392	LGG	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.T512A	TCGA-DU-6392	LGG	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.T512A	DO22237	LGG	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0833
p.T512A	DO22237	LGG	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1111
p.P674S	TCGA-EE-A182	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.P674S	DO37814	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.T446I	TCGA-EE-A183	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.7078
p.T446I	DO37715	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.7078
p.P876S	TCGA-EE-A29D	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.P876S	DO229446	SKCA	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.P876S	DO218849	SKCA	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.P876S	DO38123	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.G894E	TCGA-EE-A29D	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.G894E	DO38123	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.D791N	TCGA-EE-A29M	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.0556
p.D791N	TCGA-FS-A1ZZ	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.0556
p.D791N	DO37412	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.0556
p.D791N	DO37404	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.0556
p.P442S	TCGA-EE-A2M8	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.P442S	DO38075	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.3056
p.G1044E	TCGA-EE-A2MT	SKCM	TCGA	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2778
p.G1044E	DO38051	SKCM	ICGC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.2778
p.G894R	TCGA-EE-A3AG	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.G894R	DO37471	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.G894R	SIDM00545	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.G894R	ACH-000987	Skin Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.G894R	Mewo	skin	COSMIC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.S186L	TCGA-EO-A3AY	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.6556
p.S186L	TCGA-F5-6863	READ	TCGA	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.6556
p.S186L	DO37042	READ	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.6556
p.S186L	DO43202	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.6556
p.S804F	TCGA-ER-A193	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.7982
p.S804F	DO47368	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation altering degron motif	0.7982
p.P443L	TCGA-ER-A194	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.7582
p.P443L	DO47646	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation altering degron motif	0.7582
p.S1031F	TCGA-ER-A19A	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.7982
p.S1031F	DO47425	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.7982
p.S1023N	TCGA-G4-6304	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1667
p.S1023N	DO10639	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1667
p.P876L	TCGA-GN-A266	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.P876L	DO37432	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.P876L	SIDM01397	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.P876L	ACH-000765	Skin Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1389
p.D496E	TCGA-HR-A5NC	SKCM	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.3056
p.D496E	TCGA-HR-A5NC	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.D496E	DO51265	SKCM	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.3056
p.D496E	DO51265	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.S794R	TCGA-HU-A4GH	STAD	TCGA	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1389
p.S794R	DO47743	STAD	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1389
p.A490S	TCGA-IB-7651	PAAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1389
p.A490S	TCGA-IB-7651	PAAD	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.A490S	DO46657	PAAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1389
p.A490S	DO46657	PAAD	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.V487F	TCGA-K4-A3WS	BLCA	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0556
p.V487F	DO480	BLCA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0556
p.S1023R	TCGA-LN-A49R	ESCA	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1667
p.A491S	TCGA-MP-A4SV	LUAD	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491S	TCGA-MP-A4SV	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	DO45339	LUAD	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491S	DO45339	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	SIDM00049	Colorectal Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491S	SIDM00049	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	ACH-002233	Colon/Colorectal Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491S	ACH-002233	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491S	DIFI	large intestine	COSMIC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491S	DIFI	large intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.M450I	TCGA-O2-A52S	LUSC	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.M450I	TCGA-YD-A9TB	SKCM	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.M450I	DO219221	LUSC	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.M450I	DO51297	SKCM	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.A490T	TCGA-UF-A71B	HNSC	TCGA	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1389
p.A490T	TCGA-UF-A71B	HNSC	TCGA	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.A490T	DO52107	HNSC	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1389
p.A490T	DO52107	HNSC	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.S1033L	TCGA-ZF-A9R4	BLCA	TCGA	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.7667
p.S1033L	DO219061	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.7667
p.E452D	TCGA-ZF-AA51	BLCA	TCGA	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1944
p.E452D	DO219093	BLCA	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1944
p.A879T	DO225386	BRCA	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.2222
p.F792V	DO222762	COCA	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.0833
p.F875C	DO222884	COCA	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1111
p.S1031Y	DO222800	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.712
p.V799A	DO228114	EOPC	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2778
p.T884A	DO50446	ESAD	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation altering degron motif	0.7139
p.R882I	DO234225	ESAD	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.3056
p.S794G	DO234230	ESAD	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1389
p.S503F	DO48244	ESCA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation altering degron motif	0.7982
p.S503F	DO48244	ESCA	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7982
p.S503F	SIDM01735	Biliary Tract Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation altering degron motif	0.7982
p.S503F	SIDM01735	Biliary Tract Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.7982
p.A199S	DO223069	ESCA	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.S503T	DO233761	GACA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation altering degron motif	0.6005
p.S503T	DO233761	GACA	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation altering degron motif	0.6005
p.E452G	DO233897	GACA	ICGC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1944
p.F875V	DO233840	GACA	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1111
p.V807L	DO231976	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2778
p.S1025P	DO228461	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.2222
p.V511F	DO228976	LICA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1111
p.V511F	DO228976	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.1389
p.P505T	DO228983	LICA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.2778
p.P505T	DO228983	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.3056
p.T1045I	DO50847	LICA	ICGC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.3056
p.G1041E	DO231897	LINC	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1111
p.G1041E	DO231897	LINC	ICGC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1944
p.G1041E	ACH-001856	Bile Duct Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1111
p.G1041E	ACH-001856	Bile Duct Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1944
p.T680N	DO23496	LINC	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7055
p.T680N	DO45053	LINC	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7055
p.M798T	DO23444	LINC	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.25
p.F875L	DO45299	LIRI	ICGC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.1111
p.W1059L	DO230525	LUSC	ICGC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0833
p.S182G	DO231007	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.L668M	DO231152	LUSC	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1111
p.N683S	DO228406	MALY	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.25
p.P675S	DO220894	MELA	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.3056
p.P675S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.3056
p.P676S	DO222753	MELA	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.6752
p.D496G	DO49189	PACA	ICGC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.3056
p.D496G	DO49189	PACA	ICGC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2222
p.F667L	DO221541	PACA	ICGC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.0833
p.K176N	DO229083	PRAD	ICGC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation substituting flanking lysine	0.1944
p.G1034V	DO218861	SKCA	ICGC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.3056
p.G1034V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.3056
p.G1034V	ACH-000945	Lung Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.3056
p.G1034V	NCI-H650	lung	COSMIC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.3056
p.F792C	DO218886	SKCA	ICGC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.0833
p.V198M	SIDM01300	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0833
p.S181C	SIDM00541	Colorectal Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.S181C	ACH-000926	Colon/Colorectal Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.S181C	HT55	large intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.P796H	SIDM00216	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1944
p.P796H	ACH-000989	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1944
p.P796H	SNU-175	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1944
p.S811F	SIDM00630	Breast Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1667
p.S811F	ACH-000876	Breast Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.1667
p.L1036F	SIDM00061	Ovarian Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00061	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00189	Melanoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00189	Melanoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00427	Ewing's Sarcoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00427	Ewing's Sarcoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01168	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01168	Colorectal Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00156	Neuroblastoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00156	Neuroblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00095	Glioblastoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00095	Glioblastoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00090	Ovarian Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00090	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00027	Kidney Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00027	Kidney Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00865	Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00865	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01185	Other Solid Cancers	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01185	Other Solid Cancers	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01051	Ovarian Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01051	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01102	Non-Cancerous	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01102	Non-Cancerous	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00814	Other Solid Cancers	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00814	Other Solid Cancers	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01135	Pancreatic Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01135	Pancreatic Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01084	Osteosarcoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01084	Osteosarcoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01128	Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01128	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM00760	Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM00760	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01739	Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01739	Small Cell Lung Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.L1036F	SIDM01475	Ovarian Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.25
p.L1036F	SIDM01475	Ovarian Carcinoma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.0556
p.R177K	SIDM00545	Melanoma	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.R177K	ACH-000987	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.R177K	Mewo	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.S191T	SIDM00545	Melanoma	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.S191T	ACH-000987	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.S191T	Mewo	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2778
p.E175D	SIDM00967	Ovarian Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.E175D	ACH-002181	Ovarian Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.E175D	OVCA420	ovary	COSMIC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.P1029R	SIDM00454	Rhabdomyosarcoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.7512
p.P1029R	ACH-000689	Sarcoma	CCLE	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.7512
p.P1029R	RH-18	soft tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.7512
p.I797V	SIDM01040	Ovarian Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00553	Acute Myeloid Leukemia	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00607	Glioblastoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00589	Oral Cavity Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00571	Pancreatic Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00040	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00282	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00276	Biliary Tract Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00239	Kidney Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00560	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM00591	Oral Cavity Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM01551	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM01498	Acute Myeloid Leukemia	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.I797V	SIDM01776	Plasma Cell Myeloma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.2222
p.P674T	SIDM00088	Prostate Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.P674T	PC-3	prostate	COSMIC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2778
p.A455S	SIDM00120	Prostate Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1111
p.A455S	ACH-000979	Prostate Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1111
p.A455S	DU-145	prostate	COSMIC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1111
p.A688S	SIDM00660	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1111
p.A688S	ACH-000985	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1111
p.A688S	LS-411N	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1111
p.P440R	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.P440R	ACH-002220	Lymphoma	CCLE	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.P440R	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.P440H	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.P440H	ACH-000843	Lung Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.P440H	HARA	lung	COSMIC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.25
p.D880E	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.25
p.D880E	ACH-000858	Lung Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.25
p.D880E	KNS-62	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.25
p.M798I	SIDM00488	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.25
p.M798I	ACH-002345	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.25
p.M798I	CaR-1	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	801:805	Mutation rewiring degron network	0.25
p.N683D	SIDM00837	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.25
p.N683D	ACH-000958	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.25
p.N683D	SW48	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.25
p.S1030G	SIDM00844	Burkitt's Lymphoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.5882
p.S1030G	SIDM01133	Other Solid Cancers	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.5882
p.S1030G	SIDM01318	Hepatocellular Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation altering degron motif	0.5882
p.S506F	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.25
p.S506F	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.S506F	ACH-000865	Esophageal Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.25
p.S506F	ACH-000865	Esophageal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.S506F	KYSE-450	oesophagus	COSMIC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.25
p.S506F	KYSE-450	oesophagus	COSMIC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778
p.A491T	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491T	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491T	ACH-000916	Lung Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491T	ACH-000916	Lung Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.A491T	NCI-H1573	lung	COSMIC	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.1667
p.A491T	NCI-H1573	lung	COSMIC	PPSST	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0833
p.P675H	SIDM00217	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.3056
p.P675H	ACH-000999	Colon/Colorectal Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.3056
p.P675H	SNU-1040	large intestine	COSMIC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.3056
p.R177S	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.R177S	SIDM01387	Small Cell Lung Carcinoma	GDSC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.R177S	ACH-000451	Lung Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.R177S	ACH-000921	Lung Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.R177S	NCI-H2085	lung	COSMIC	ASSTS	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.E452A	SIDM00534	Colorectal Carcinoma	GDSC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1944
p.E452A	ACH-000986	Colon/Colorectal Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1944
p.E452A	HT-115	large intestine	COSMIC	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1944
p.S1019T	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.0556
p.S1019T	ACH-000282	Lung Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.0556
p.S1019T	NCI-H1755	lung	COSMIC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.0556
p.I1038T	SIDM01696	Mesothelioma	GDSC	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1944
p.I1038T	SIDM01696	Mesothelioma	GDSC	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1111
p.I1038T	ACH-000645	Lung Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1944
p.I1038T	ACH-000645	Lung Cancer	CCLE	PSTTS	DEG_SPOP_SBC_1	1046:1050	Mutation rewiring degron network	0.1111
p.I896V	ACH-001032	Bone Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	883:887	Mutation rewiring degron network	0.0833
p.V487D	ACH-001413	Bladder Cancer	CCLE	PPTPPSS	DEG_SCF_FBW7_1	497:503	Mutation rewiring degron network	0.0556
p.L437R	ACH-001518	Endometrial/Uterine Cancer	CCLE	PLSTT	DEG_SPOP_SBC_1	443:447	Mutation rewiring degron network	0.1667
p.G1021W	ACH-001857	Bile Duct Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	1029:1033	Mutation rewiring degron network	0.1111
p.T687A	FADU	upper aerodigestive tract	COSMIC	PDTST	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPAP1

UniProt ID: Q9NZP6

Entrez ID: 23742

Protein name: Nuclear pore-associated protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPAP1 in