DegronMD

Uniprot ID: Q9NZP6

Source protein: Nuclear pore-associated protein 1

Source gene: NPAP1

Class: DEG_SPOP_SBC_1

Location: 500:504

E3 ligase: SPOP

DEGRON score: 0.8227

ASA_SCORE: 85.58

COIL: 0.9662

CONS_SCORE: 0.5752

DSS_SCORE: 0.6875

HELIX: 0.0136

FCONS_SCORE: 0.8589

RIG_SCORE: 0.5242

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P509H	TCGA-17-Z028	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.1944
p.P509H	TCGA-AX-A2HD	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	0.1944
p.P509H	DO42608	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	0.1944
p.R513T	TCGA-17-Z056	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.0833
p.F507I	TCGA-29-2434	OV	TCGA	PPSST	DEG_SPOP_SBC_1	0.25
p.F507I	DO31360	OV	ICGC	PPSST	DEG_SPOP_SBC_1	0.25
p.S495Y	TCGA-2F-A9KO	BLCA	TCGA	PPSST	DEG_SPOP_SBC_1	0.1944
p.S495Y	DO51859	BLCA	ICGC	PPSST	DEG_SPOP_SBC_1	0.1944
p.R513K	TCGA-3N-A9WC	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	0.0833
p.R513K	DO51234	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	0.0833
p.E514V	TCGA-86-8281	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.0556
p.E514V	DO26318	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.0556
p.A491V	TCGA-AA-A01Z	COAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.0833
p.A491V	DO8392	COAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.0833
p.P500R	TCGA-BB-A5HY	HNSC	TCGA	PPSST	DEG_SPOP_SBC_1	0.7512
p.P500R	DO218979	HNSC	ICGC	PPSST	DEG_SPOP_SBC_1	0.7512
p.L493H	TCGA-BR-4184	STAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.1389
p.L493H	DO38328	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.1389
p.P501R	TCGA-BR-A4QI	STAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.6401
p.P501R	DO38523	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.6401
p.D496Y	TCGA-CV-7245	HNSC	TCGA	PPSST	DEG_SPOP_SBC_1	0.2222
p.D496Y	DO14322	HNSC	ICGC	PPSST	DEG_SPOP_SBC_1	0.2222
p.T512A	TCGA-DU-6392	LGG	TCGA	PPSST	DEG_SPOP_SBC_1	0.1111
p.T512A	DO22237	LGG	ICGC	PPSST	DEG_SPOP_SBC_1	0.1111
p.D496E	TCGA-HR-A5NC	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	0.2222
p.D496E	DO51265	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	0.2222
p.A490S	TCGA-IB-7651	PAAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.0556
p.A490S	DO46657	PAAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.0556
p.A491S	TCGA-MP-A4SV	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	0.0833
p.A491S	DO45339	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	0.0833
p.A491S	SIDM00049	Colorectal Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.0833
p.A491S	ACH-002233	Colon/Colorectal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	0.0833
p.A491S	DIFI	large_intestine	COSMIC	PPSST	DEG_SPOP_SBC_1	0.0833
p.A490T	TCGA-UF-A71B	HNSC	TCGA	PPSST	DEG_SPOP_SBC_1	0.0556
p.A490T	DO52107	HNSC	ICGC	PPSST	DEG_SPOP_SBC_1	0.0556
p.S503F	DO48244	ESCA	ICGC	PPSST	DEG_SPOP_SBC_1	0.7982
p.S503F	SIDM01735	Biliary Tract Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.7982
p.S503T	DO233761	GACA	ICGC	PPSST	DEG_SPOP_SBC_1	0.6005
p.V511F	DO228976	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	0.1389
p.P505T	DO228983	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	0.3056
p.D496G	DO49189	PACA	ICGC	PPSST	DEG_SPOP_SBC_1	0.2222
p.S506F	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.2778
p.S506F	ACH-000865	Esophageal Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	0.2778
p.S506F	KYSE-450	oesophagus	COSMIC	PPSST	DEG_SPOP_SBC_1	0.2778
p.A491T	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	0.0833
p.A491T	ACH-000916	Lung Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	0.0833
p.A491T	NCI-H1573	lung	COSMIC	PPSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	2967:2971	PPSST	SPOP	0.9664	More...
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	646:650	PPSST	SPOP	0.9933	More...
P15529	Membrane cofactor protein	DEG_SPOP_SBC_1	288:292	PPSST	SPOP	0.9554	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	1220:1224	PPSST	SPOP	0.727	More...
P32243	Homeobox protein OTX2	DEG_SPOP_SBC_1	133:137	PPSST	SPOP	0.9927	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1621:1625	PPSST	SPOP	0.9359	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	3028:3032	PPSST	SPOP	0.7211	More...
Q02641	Voltage-dependent L-type calcium channel subunit beta-1	DEG_SPOP_SBC_1	414:418	PPSST	SPOP	0.8892	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	735:739	PPSST	SPOP	0.8425	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	1361:1365	PPSST	SPOP	0.9538	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1645:1649	PPSST	SPOP	0.9971	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	915:919	PPSST	SPOP	0.9866	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	24:28	PPSST	SPOP	0.9977	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	500:504	PPSST	SPOP	0.7702	More...
Q86SQ0	Pleckstrin homology-like domain family B member 2	DEG_SPOP_SBC_1	553:557	PPSST	SPOP	0.7645	More...
Q86WP2	Vasculin	DEG_SPOP_SBC_1	16:20	PPSST	SPOP	0.9896	More...
Q8IUC6	TIR domain-containing adapter molecule 1	DEG_SPOP_SBC_1	366:370	PPSST	SPOP	0.9854	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1852:1856	PPSST	SPOP	0.9444	More...
Q8N8W4	Omega-hydroxyceramide transacylase	DEG_SPOP_SBC_1	380:384	PPSST	SPOP	0.9792	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	582:586	PPSST	SPOP	0.9689	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	931:935	PPSST	SPOP	0.8254	More...
Q9H0X9	Oxysterol-binding protein-related protein 5	DEG_SPOP_SBC_1	15:19	PPSST	SPOP	0.9979	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	880:884	PPSST	SPOP	0.9899	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	500:504	PPSST	SPOP	0.8227	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1673:1677	PPSST	SPOP	0.5462	More...
Q9UJ78	Zinc finger MYM-type protein 5	DEG_SPOP_SBC_1	489:493	PPSST	SPOP	0.8233	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	66:70	PPSST	SPOP	0.9674	More...
Q76G19	PDZ domain-containing protein 4	DEG_SPOP_SBC_1	302:306	PPSST	SPOP	0.8947	More...
Q7L0X2	Glutamate-rich protein 6	DEG_SPOP_SBC_1	126:130	PPSST	SPOP	0.8085	More...
Q5VWI1	Transcription elongation regulator 1-like protein	DEG_SPOP_SBC_1	127:131	PPSST	SPOP	0.9468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSST

Degron related mutations and impact score

Drug responses associated with NPAP1 mutations

All proteins holding degron of PPSST