DegronMD - P32243(OTX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S143Y	TCGA-96-7544	LUSC	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.3056
p.S143Y	TCGA-96-7544	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1667
p.S143Y	DO26425	LUSC	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.3056
p.S143Y	DO26425	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1667
p.P125T	TCGA-AP-A1DV	UCEC	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1389
p.P125T	TCGA-AP-A1DV	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.P125T	DO43186	UCEC	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1389
p.P125T	DO43186	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.P125S	TCGA-D3-A8GI	SKCM	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1389
p.P125S	TCGA-D3-A8GI	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.P125S	TCGA-S5-A6DX	BLCA	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1389
p.P125S	TCGA-S5-A6DX	BLCA	TCGA	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.P125S	DO51903	BLCA	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1389
p.P125S	DO51903	BLCA	ICGC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.P125S	DO50284	SKCM	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1389
p.P125S	DO50284	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.F139S	TCGA-E6-A1LX	UCEC	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.7982
p.F139S	DO41020	UCEC	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.7982
p.P125A	TCGA-OR-A5JS	ACC	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1389
p.P125A	TCGA-OR-A5JS	ACC	TCGA	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.P141S	TCGA-W5-AA31	CHOL	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.6752
p.S136N	DO48457	BLCA	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.5958
p.S136N	DO48457	BLCA	ICGC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.7069
p.T140N	DO228971	LICA	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.7055
p.A151V	DO51469	PACA	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.0833
p.E132D	SIDM00963	Breast Carcinoma	GDSC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.6758
p.E132D	BT-474	breast	COSMIC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.6758
p.E128G	SIDM00251	Gastric Carcinoma	GDSC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.2222
p.E128G	SIDM00251	Gastric Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.E128G	TGBC11TKB	stomach	COSMIC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.2222
p.E128G	TGBC11TKB	stomach	COSMIC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.S136G	SIDM01575	Plasma Cell Myeloma	GDSC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.5882
p.S136G	SIDM01575	Plasma Cell Myeloma	GDSC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.6993
p.S128G	ACH-000426	Myeloma	CCLE	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.2222
p.S128G	ACH-000426	Myeloma	CCLE	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.E124D	ACH-000927	Breast Cancer	CCLE	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1111
p.E124D	ACH-000927	Breast Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.E124D	BT-474	breast	COSMIC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.1111
p.E124D	BT-474	breast	COSMIC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.S123L	ACH-001411	Bladder Cancer	CCLE	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.0833
p.S123L	ACH-001411	Bladder Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.Q130R	ACH-002508	Skin Cancer	CCLE	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.2778
p.Q130R	ACH-002508	Skin Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.25

Kaplan plot for OTX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTX2

UniProt ID: P32243

Entrez ID: 5015

Protein name: Homeobox protein OTX2 (Orthodenticle homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTX2 in