DegronMD - P32243(OTX2)

FUNCTION: Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. {ECO:0000269|PubMed:22715480}.

GO - Biological processes (BP): axon guidance [GO:0007411]; dopaminergic neuron differentiation [GO:0071542]; forebrain development [GO:0030900]; midbrain development [GO:0030901]; positive regulation of embryonic development [GO:0040019]; positive regulation of gastrulation [GO:2000543]; positive regulation of transcription, DNA-... View more >>

GO - Molecular function (MF): DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; eukaryotic initiation factor 4E binding [GO:0008190]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; growth cone [GO:0030426]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F139S	TCGA-E6-A1LX	UCEC	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.7982
p.F139S	DO41020	UCEC	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.7982
p.S136N	DO48457	BLCA	ICGC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.7069
p.T140N	DO228971	LICA	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.7055
p.S136G	SIDM01575	Plasma Cell Myeloma	GDSC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.6993
p.E132D	SIDM00963	Breast Carcinoma	GDSC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.6758
p.E132D	BT-474	breast	COSMIC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.6758
p.P141S	TCGA-W5-AA31	CHOL	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.6752
p.S136N	DO48457	BLCA	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.5958
p.S136G	SIDM01575	Plasma Cell Myeloma	GDSC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation altering degron motif	0.5882
p.S143Y	TCGA-96-7544	LUSC	TCGA	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.3056
p.S143Y	DO26425	LUSC	ICGC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.3056
p.Q130R	ACH-002508	Skin Cancer	CCLE	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.2778
p.Q130R	ACH-002508	Skin Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.25
p.E128G	SIDM00251	Gastric Carcinoma	GDSC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.2222
p.E128G	TGBC11TKB	stomach	COSMIC	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.2222
p.S128G	ACH-000426	Myeloma	CCLE	TPPSSTSVPTI	DEG_COP1_1	132:142	Mutation rewiring degron network	0.2222
p.E128G	SIDM00251	Gastric Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.E128G	TGBC11TKB	stomach	COSMIC	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.S128G	ACH-000426	Myeloma	CCLE	PPSST	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 43 entries

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Kaplan plot for OTX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OTX2

UniProt ID: P32243

Entrez ID: 5015

Protein name: Homeobox protein OTX2 (Orthodenticle homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OTX2 in