DegronMD

Uniprot ID: P32243

Source protein: Homeobox protein OTX2

Source gene: OTX2

Class: DEG_COP1_1

Location: 132:142

E3 ligase: COP1

DEGRON score: 0.9905

ASA_SCORE: 68.9

COIL: 0.944

CONS_SCORE: 0.4732

DSS_SCORE: 0.5459

HELIX: 0.0295

FCONS_SCORE: 0.9507

RIG_SCORE: 0.6304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S143Y	TCGA-96-7544	LUSC	TCGA	TPPSSTSVPTI	DEG_COP1_1	0.3056
p.S143Y	DO26425	LUSC	ICGC	TPPSSTSVPTI	DEG_COP1_1	0.3056
p.P125T	TCGA-AP-A1DV	UCEC	TCGA	TPPSSTSVPTI	DEG_COP1_1	0.1389
p.P125T	DO43186	UCEC	ICGC	TPPSSTSVPTI	DEG_COP1_1	0.1389
p.P125S	TCGA-D3-A8GI	SKCM	TCGA	TPPSSTSVPTI	DEG_COP1_1	0.1389
p.P125S	TCGA-S5-A6DX	BLCA	TCGA	TPPSSTSVPTI	DEG_COP1_1	0.1389
p.P125S	DO51903	BLCA	ICGC	TPPSSTSVPTI	DEG_COP1_1	0.1389
p.P125S	DO50284	SKCM	ICGC	TPPSSTSVPTI	DEG_COP1_1	0.1389
p.F139S	TCGA-E6-A1LX	UCEC	TCGA	TPPSSTSVPTI	DEG_COP1_1	0.7982
p.F139S	DO41020	UCEC	ICGC	TPPSSTSVPTI	DEG_COP1_1	0.7982
p.P125A	TCGA-OR-A5JS	ACC	TCGA	TPPSSTSVPTI	DEG_COP1_1	0.1389
p.P141S	TCGA-W5-AA31	CHOL	TCGA	TPPSSTSVPTI	DEG_COP1_1	0.6752
p.S136N	DO48457	BLCA	ICGC	TPPSSTSVPTI	DEG_COP1_1	0.5958
p.T140N	DO228971	LICA	ICGC	TPPSSTSVPTI	DEG_COP1_1	0.7055
p.A151V	DO51469	PACA	ICGC	TPPSSTSVPTI	DEG_COP1_1	0.0833
p.E132D	SIDM00963	Breast Carcinoma	GDSC	TPPSSTSVPTI	DEG_COP1_1	0.6758
p.E132D	BT-474	breast	COSMIC	TPPSSTSVPTI	DEG_COP1_1	0.6758
p.E128G	SIDM00251	Gastric Carcinoma	GDSC	TPPSSTSVPTI	DEG_COP1_1	0.2222
p.E128G	TGBC11TKB	stomach	COSMIC	TPPSSTSVPTI	DEG_COP1_1	0.2222
p.S136G	SIDM01575	Plasma Cell Myeloma	GDSC	TPPSSTSVPTI	DEG_COP1_1	0.5882
p.S128G	ACH-000426	Myeloma	CCLE	TPPSSTSVPTI	DEG_COP1_1	0.2222
p.E124D	ACH-000927	Breast Cancer	CCLE	TPPSSTSVPTI	DEG_COP1_1	0.1111
p.E124D	BT-474	breast	COSMIC	TPPSSTSVPTI	DEG_COP1_1	0.1111
p.S123L	ACH-001411	Bladder Cancer	CCLE	TPPSSTSVPTI	DEG_COP1_1	0.0833
p.Q130R	ACH-002508	Skin Cancer	CCLE	TPPSSTSVPTI	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32243	Homeobox protein OTX2	DEG_COP1_1	132:142	TPPSSTSVPTI	COP1	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons