DegronMD - Q76L83(ASXL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N1332S	TCGA-24-2295	OV	TCGA	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.3056
p.N1332S	TCGA-RC-A6M3	LIHC	TCGA	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.3056
p.N1332S	DO223914	LIHC	ICGC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.3056
p.N1332S	DO32173	OV	ICGC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.3056
p.A796S	TCGA-43-2581	LUSC	TCGA	VPPTPAVS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0556
p.A796S	DO26602	LUSC	ICGC	VPPTPAVS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0556
p.N936S	TCGA-91-6831	LUAD	TCGA	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.2222
p.N936S	DO23753	LUAD	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.2222
p.M935I	TCGA-A5-A2K5	UCEC	TCGA	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.25
p.M935I	DO41379	UCEC	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.25
p.S136L	TCGA-AA-3977	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7667
p.S136L	DO8730	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.7667
p.E125D	TCGA-AA-A022	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.E125D	DO10647	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.0556
p.G937E	TCGA-AP-A056	UCEC	TCGA	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.1944
p.G937E	DO43971	UCEC	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.1944
p.S146L	TCGA-BT-A20T	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation blocking phosphorylation signal	0.5833
p.S146L	DO804	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation blocking phosphorylation signal	0.5833
p.A922V	TCGA-CG-4305	STAD	TCGA	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.2222
p.A922V	TCGA-CG-4305	STAD	TCGA	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.25
p.A922V	DO38823	STAD	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.2222
p.A922V	DO38823	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.25
p.G1324W	TCGA-D3-A1Q1	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.0833
p.G1324W	DO37445	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.0833
p.V135A	TCGA-EO-A3AS	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.5825
p.V135A	DO43466	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.5825
p.S139F	TCGA-FW-A3R5	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.9093
p.S139F	DO234425	ESAD	ICGC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.9093
p.S139F	DO37406	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation altering degron motif	0.9093
p.G1324V	TCGA-GF-A2C7	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.0833
p.G1324V	DO37407	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.0833
p.P1325S	TCGA-IB-7651	PAAD	TCGA	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1111
p.P1325S	DO46657	PAAD	ICGC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1111
p.C144F	TCGA-L5-A8NW	ESCA	TCGA	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1944
p.S917L	TCGA-ND-A4WC	UCS	TCGA	PPSST	DEG_SPOP_SBC_1	915:919	Mutation altering degron motif	0.7667
p.S917L	DO227717	COCA	ICGC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation altering degron motif	0.7667
p.S1343F	TCGA-SY-A9G5	BLCA	TCGA	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1667
p.S1343F	DO51906	BLCA	ICGC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1667
p.S925G	TCGA-VQ-A91E	STAD	TCGA	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.3056
p.S925G	TCGA-VQ-A91E	STAD	TCGA	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1667
p.S925G	DO51784	STAD	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.3056
p.S925G	DO51784	STAD	ICGC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1667
p.A909S	DO230312	COCA	ICGC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1667
p.A909S	DO222874	COCA	ICGC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1667
p.A914T	DO222540	COCA	ICGC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.3056
p.V785I	DO234170	ESAD	ICGC	VPPTPAVS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.5965
p.V785I	SIDM00217	Colorectal Carcinoma	GDSC	VPPTPAVS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.5965
p.P795A	DO233853	GACA	ICGC	VPPTPAVS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.0833
p.P921T	DO228978	LICA	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.1944
p.P921T	DO228978	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.2778
p.P921T	DO229019	LICA	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.1944
p.P921T	DO229019	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.2778
p.T931N	DO229022	LICA	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation altering degron motif	0.5944
p.P145Q	DO229026	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.1667
p.Y1327C	DO231672	LINC	ICGC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1667
p.Q141H	DO34841	PACA	ICGC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2778
p.P942L	DO229453	SKCA	ICGC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.0556
p.G143D	SIDM02021	Esophageal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	135:139	Mutation rewiring degron network	0.2222
p.P1325R	SIDM00428	Acute Myeloid Leukemia	GDSC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1111
p.P1325R	SIDM01182	Bladder Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1111
p.P1325R	UM-UC-3	urinary tract	COSMIC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1111
p.P1325R	NB-4	haematopoietic and lymphoid tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1111
p.V1345I	SIDM00845	Burkitt's Lymphoma	GDSC	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1111
p.V1345I	ACH-000786	Lymphoma	CCLE	VSTSS	DEG_SPOP_SBC_1	1333:1337	Mutation rewiring degron network	0.1111
p.L933S	SIDM00845	Burkitt's Lymphoma	GDSC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.3056
p.L933V	SIDM00845	Burkitt's Lymphoma	GDSC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.3056
p.P916S	SIDM00845	Burkitt's Lymphoma	GDSC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation altering degron motif	0.5641
p.P938H	SIDM00950	Pancreatic Carcinoma	GDSC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.1667
p.P938H	ACH-000243	Pancreatic Cancer	CCLE	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.1667
p.P938H	DAN-G	pancreas	COSMIC	LKTPGTS	DEG_SCF_FBW7_1	926:932	Mutation rewiring degron network	0.1667
p.G912V	SIDM01170	Ovarian Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.25
p.G912V	ACH-000048	Ovarian Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.25
p.G912V	TOV-112D	ovary	COSMIC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.25
p.P910H	DAN-G	pancreas	COSMIC	PPSST	DEG_SPOP_SBC_1	915:919	Mutation rewiring degron network	0.1944
p.D774G	COLO-783	skin	COSMIC	VPPTPAVS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1944
p.P792L	SK-NEP-1	kidney	COSMIC	VPPTPAVS	DEG_SCF_FBW7_1	779:786	Mutation rewiring degron network	0.1667
p.P780L	HCC202	breast	COSMIC	VPPTPAVS	DEG_SCF_FBW7_1	779:786	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASXL2

UniProt ID: Q76L83

Entrez ID: 55252

Protein name: Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASXL2 in