DegronMD

Uniprot ID: Q76L83

Source protein: Putative Polycomb group protein ASXL2

Source gene: ASXL2

Class: DEG_SCF_FBW7_1

Location: 926:932

E3 ligase: FBXW7

DEGRON score: 0.9522

ASA_SCORE: 94.2571

COIL: 0.9571

CONS_SCORE: 0.326

DSS_SCORE: 0.6165

HELIX: 0.0207

FCONS_SCORE: 0.89

RIG_SCORE: 0.614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N936S	TCGA-91-6831	LUAD	TCGA	LKTPGTS	DEG_SCF_FBW7_1	0.2222
p.N936S	DO23753	LUAD	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.2222
p.M935I	TCGA-A5-A2K5	UCEC	TCGA	LKTPGTS	DEG_SCF_FBW7_1	0.25
p.M935I	DO41379	UCEC	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.25
p.G937E	TCGA-AP-A056	UCEC	TCGA	LKTPGTS	DEG_SCF_FBW7_1	0.1944
p.G937E	DO43971	UCEC	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.1944
p.A922V	TCGA-CG-4305	STAD	TCGA	LKTPGTS	DEG_SCF_FBW7_1	0.2222
p.A922V	DO38823	STAD	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.2222
p.S925G	TCGA-VQ-A91E	STAD	TCGA	LKTPGTS	DEG_SCF_FBW7_1	0.3056
p.S925G	DO51784	STAD	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.3056
p.P921T	DO228978	LICA	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.1944
p.P921T	DO229019	LICA	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.1944
p.T931N	DO229022	LICA	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.5944
p.P942L	DO229453	SKCA	ICGC	LKTPGTS	DEG_SCF_FBW7_1	0.0556
p.L933S	SIDM00845	Burkitt's Lymphoma	GDSC	LKTPGTS	DEG_SCF_FBW7_1	0.3056
p.L933V	SIDM00845	Burkitt's Lymphoma	GDSC	LKTPGTS	DEG_SCF_FBW7_1	0.3056
p.P938H	SIDM00950	Pancreatic Carcinoma	GDSC	LKTPGTS	DEG_SCF_FBW7_1	0.1667
p.P938H	ACH-000243	Pancreatic Cancer	CCLE	LKTPGTS	DEG_SCF_FBW7_1	0.1667
p.P938H	DAN-G	pancreas	COSMIC	LKTPGTS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76L83	Putative Polycomb group protein ASXL2	DEG_SCF_FBW7_1	926:932	LKTPGTS	FBXW7	0.9522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons