DegronMD

Uniprot ID: Q76L83

Source protein: Putative Polycomb group protein ASXL2

Source gene: ASXL2

Class: DEG_SPOP_SBC_1

Location: 1333:1337

E3 ligase: SPOP

DEGRON score: 0.961

ASA_SCORE: 66.92

COIL: 0.7306

CONS_SCORE: 0.3897

DSS_SCORE: 0.506

HELIX: 0.0584

FCONS_SCORE: 1.0761

RIG_SCORE: 0.685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1332S	TCGA-24-2295	OV	TCGA	VSTSS	DEG_SPOP_SBC_1	0.3056
p.N1332S	TCGA-RC-A6M3	LIHC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.3056
p.N1332S	DO223914	LIHC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.3056
p.N1332S	DO32173	OV	ICGC	VSTSS	DEG_SPOP_SBC_1	0.3056
p.G1324W	TCGA-D3-A1Q1	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0833
p.G1324W	DO37445	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.G1324V	TCGA-GF-A2C7	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0833
p.G1324V	DO37407	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.P1325S	TCGA-IB-7651	PAAD	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P1325S	DO46657	PAAD	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.S1343F	TCGA-SY-A9G5	BLCA	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1667
p.S1343F	DO51906	BLCA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1667
p.Y1327C	DO231672	LINC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1667
p.P1325R	SIDM00428	Acute Myeloid Leukemia	GDSC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P1325R	SIDM01182	Bladder Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P1325R	UM-UC-3	urinary_tract	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P1325R	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.V1345I	SIDM00845	Burkitt's Lymphoma	GDSC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.V1345I	ACH-000786	Lymphoma	CCLE	VSTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_SPOP_SBC_1	339:343	VSTSS	SPOP	0.9784	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SPOP_SBC_1	816:820	VSTSS	SPOP	0.9961	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	38:42	VSTSS	SPOP	0.9947	More...
P57768	Sorting nexin-16	DEG_SPOP_SBC_1	33:37	VSTSS	SPOP	0.9979	More...
Q14149	MORC family CW-type zinc finger protein 3	DEG_SPOP_SBC_1	872:876	VSTSS	SPOP	0.9439	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	776:780	VSTSS	SPOP	0.6894	More...
Q6PJT7	Zinc finger CCCH domain-containing protein 14	DEG_SPOP_SBC_1	131:135	VSTSS	SPOP	0.9971	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	1333:1337	VSTSS	SPOP	0.961	More...
Q7L1W4	Volume-regulated anion channel subunit LRRC8D	DEG_SPOP_SBC_1	238:242	VSTSS	SPOP	0.6957	More...
Q86UE8	Serine/threonine-protein kinase tousled-like 2	DEG_SPOP_SBC_1	749:753	VSTSS	SPOP	0.9974	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1839:1843	VSTSS	SPOP	0.9049	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	569:573	VSTSS	SPOP	0.9917	More...
Q8TF72	Protein Shroom3	DEG_SPOP_SBC_1	815:819	VSTSS	SPOP	0.9994	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	162:166	VSTSS	SPOP	0.9894	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	888:892	VSTSS	SPOP	0.9942	More...
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SPOP_SBC_1	3049:3053	VSTSS	SPOP	0.9533	More...
Q9BQE6	LBH domain-containing protein 1	DEG_SPOP_SBC_1	51:55	VSTSS	SPOP	0.5933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons