DegronMD

Uniprot ID: Q8NFU7

Source protein: Methylcytosine dioxygenase TET1

Source gene: TET1

Class: DEG_SPOP_SBC_1

Location: 569:573

E3 ligase: SPOP

DEGRON score: 0.9917

ASA_SCORE: 87.62

COIL: 0.9492

CONS_SCORE: 0.2843

DSS_SCORE: 0.3754

HELIX: 0.0246

FCONS_SCORE: 0.853

RIG_SCORE: 0.7584

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S570N	ACH-002287	Colon/Colorectal Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	0.5958
p.S570N	NCI-H630	large_intestine	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.5958
p.S570G	SIDM01090	Colorectal Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	0.5882
p.V566L	DO229018	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.25
p.T563N	TCGA-13-1500	OV	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1667
p.T563N	DO29698	OV	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1667
p.P581L	TCGA-AA-A01C	COAD	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P581L	TCGA-AX-A1CE	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P581L	DO7781	COAD	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P581L	DO228338	MALY	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P581L	DO42280	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P581L	SIDM00948	Burkitt's Lymphoma	GDSC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P581L	ACH-002232	Lymphoma	CCLE	VSTSS	DEG_SPOP_SBC_1	0.1111
p.P581L	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.1111
p.T559A	TCGA-AP-A0LD	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0556
p.T559A	DO41578	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.0556
p.L583F	TCGA-D7-A6EZ	STAD	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0556
p.L583F	DO50119	STAD	ICGC	VSTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54259	Atrophin-1	DEG_SPOP_SBC_1	38:42	VSTSS	SPOP	0.9947	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	776:780	VSTSS	SPOP	0.6894	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1839:1843	VSTSS	SPOP	0.9049	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	162:166	VSTSS	SPOP	0.9894	More...
Q9BQE6	LBH domain-containing protein 1	DEG_SPOP_SBC_1	51:55	VSTSS	SPOP	0.5933	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	569:573	VSTSS	SPOP	0.9917	More...
Q14149	MORC family CW-type zinc finger protein 3	DEG_SPOP_SBC_1	872:876	VSTSS	SPOP	0.9439	More...
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SPOP_SBC_1	3049:3053	VSTSS	SPOP	0.9533	More...
Q8TF72	Protein Shroom3	DEG_SPOP_SBC_1	815:819	VSTSS	SPOP	0.9994	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	1333:1337	VSTSS	SPOP	0.961	More...
Q86UE8	Serine/threonine-protein kinase tousled-like 2	DEG_SPOP_SBC_1	749:753	VSTSS	SPOP	0.9974	More...
P57768	Sorting nexin-16	DEG_SPOP_SBC_1	33:37	VSTSS	SPOP	0.9979	More...
P35716	Transcription factor SOX-11	DEG_SPOP_SBC_1	339:343	VSTSS	SPOP	0.9784	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SPOP_SBC_1	816:820	VSTSS	SPOP	0.9961	More...
Q7L1W4	Volume-regulated anion channel subunit LRRC8D	DEG_SPOP_SBC_1	238:242	VSTSS	SPOP	0.6957	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	888:892	VSTSS	SPOP	0.9942	More...
Q6PJT7	Zinc finger CCCH domain-containing protein 14	DEG_SPOP_SBC_1	131:135	VSTSS	SPOP	0.9971	More...

Showing 1 to 17 of 17 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons