DegronMD - Q7L1W4(LRRC8D)

LRRC8D

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S242N	TCGA-12-0707	GBM	TCGA	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.818
p.S242N	DO12634	GBM	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation altering degron motif	0.818
p.T229A	TCGA-AP-A051	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0833
p.T229A	DO42673	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0833
p.Q232K	TCGA-CN-6010	HNSC	TCGA	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.Q232K	TCGA-D9-A148	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.Q232K	DO14766	HNSC	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.Q232K	DO37971	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.P252Q	TCGA-EE-A183	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0556
p.P252Q	DO37715	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.0556
p.G245R	TCGA-GN-A266	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.25
p.G245R	DO37432	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.25
p.Q232H	TCGA-KU-A6H7	HNSC	TCGA	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.Q232H	DO52089	HNSC	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation rewiring degron network	0.1667
p.S246I	DO229041	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation blocking phosphorylation signal	0.6667
p.S246N	DO35242	PACA	ICGC	VSTSS	DEG_SPOP_SBC_1	238:242	Mutation blocking phosphorylation signal	0.6667

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*NOTE: the Kaplan plots were collected from OncoLnc