DegronMD

Uniprot ID: Q7L1W4

Source protein: Volume-regulated anion channel subunit LRRC8D

Source gene: LRRC8D

Class: DEG_SPOP_SBC_1

Location: 238:242

E3 ligase: SPOP

DEGRON score: 0.6957

ASA_SCORE: 72.32

COIL: 0.8384

CONS_SCORE: 0.6257

DSS_SCORE: 0.6751

HELIX: 0.0754

FCONS_SCORE: 1.1674

RIG_SCORE: 0.6138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S242N	TCGA-12-0707	GBM	TCGA	VSTSS	DEG_SPOP_SBC_1	0.818
p.S242N	DO12634	GBM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.818
p.T229A	TCGA-AP-A051	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0833
p.T229A	DO42673	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.0833
p.Q232K	TCGA-CN-6010	HNSC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1667
p.Q232K	TCGA-D9-A148	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1667
p.Q232K	DO14766	HNSC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1667
p.Q232K	DO37971	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1667
p.P252Q	TCGA-EE-A183	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	0.0556
p.P252Q	DO37715	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.0556
p.G245R	TCGA-GN-A266	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	0.25
p.G245R	DO37432	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.25
p.Q232H	TCGA-KU-A6H7	HNSC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1667
p.Q232H	DO52089	HNSC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1667
p.S246I	DO229041	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.6667
p.S246N	DO35242	PACA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_SPOP_SBC_1	339:343	VSTSS	SPOP	0.9784	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SPOP_SBC_1	816:820	VSTSS	SPOP	0.9961	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	38:42	VSTSS	SPOP	0.9947	More...
P57768	Sorting nexin-16	DEG_SPOP_SBC_1	33:37	VSTSS	SPOP	0.9979	More...
Q14149	MORC family CW-type zinc finger protein 3	DEG_SPOP_SBC_1	872:876	VSTSS	SPOP	0.9439	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	776:780	VSTSS	SPOP	0.6894	More...
Q6PJT7	Zinc finger CCCH domain-containing protein 14	DEG_SPOP_SBC_1	131:135	VSTSS	SPOP	0.9971	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	1333:1337	VSTSS	SPOP	0.961	More...
Q7L1W4	Volume-regulated anion channel subunit LRRC8D	DEG_SPOP_SBC_1	238:242	VSTSS	SPOP	0.6957	More...
Q86UE8	Serine/threonine-protein kinase tousled-like 2	DEG_SPOP_SBC_1	749:753	VSTSS	SPOP	0.9974	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1839:1843	VSTSS	SPOP	0.9049	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	569:573	VSTSS	SPOP	0.9917	More...
Q8TF72	Protein Shroom3	DEG_SPOP_SBC_1	815:819	VSTSS	SPOP	0.9994	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	162:166	VSTSS	SPOP	0.9894	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	888:892	VSTSS	SPOP	0.9942	More...
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SPOP_SBC_1	3049:3053	VSTSS	SPOP	0.9533	More...
Q9BQE6	LBH domain-containing protein 1	DEG_SPOP_SBC_1	51:55	VSTSS	SPOP	0.5933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons