DegronMD - Q9NZM3(ITSN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G190E	TCGA-2L-AAQJ	PAAD	TCGA	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1944
p.G190E	DO218949	PAAD	ICGC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1944
p.L195V	TCGA-86-6851	LUAD	TCGA	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.L195V	DO23798	LUAD	ICGC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.S166L	TCGA-96-A4JK	LUSC	TCGA	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7667
p.S166L	DO45442	LUSC	ICGC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.7667
p.S837F	TCGA-98-8021	LUSC	TCGA	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.25
p.S839C	TCGA-C8-A12Q	BRCA	TCGA	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.3056
p.P853Q	TCGA-ER-A19T	SKCM	TCGA	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.0833
p.P157L	TCGA-ER-A2NH	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.P157L	DO47683	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.S161F	TCGA-FS-A1ZA	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.S161F	DO37551	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.3056
p.A851P	DO52738	CMDI	ICGC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1389
p.P188S	DO48223	ESCA	ICGC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.A172T	DO233210	GACA	ICGC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1667
p.A172T	DO233210	GACA	ICGC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0833
p.S850T	DO233784	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1667
p.W846R	DO233888	GACA	ICGC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.2778
p.S163N	DO233899	GACA	ICGC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation altering degron motif	0.5958
p.T171N	DO229036	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.1944
p.T171N	DO229036	LICA	ICGC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.H189N	DO231026	LUSC	ICGC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.2222
p.P181S	DO220908	MELA	ICGC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6752
p.G170R	DO49142	PACA	ICGC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2222
p.P168Q	DO227710	PBCA	ICGC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.2778
p.R854L	DO47442	SKCM	ICGC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.0556
p.N839S	DO43186	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.3056
p.S836Y	DO42793	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.2222
p.R854Q	DO41379	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.0556
p.P179S	SIDM00845	Burkitt's Lymphoma	GDSC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.2778
p.P179S	SIDM01519	Head and Neck Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.2778
p.S185L	SIDM00694	Other Solid Cancers	GDSC	PYSSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.7667
p.S850L	SIDM01561	Melanoma	GDSC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1667
p.S850L	ACH-000799	Skin Cancer	CCLE	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.1667
p.V159L	ACH-000973	Bladder Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.25
p.A153V	ALL-PO	haematopoietic and lymphoid tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	162:166	Mutation rewiring degron network	0.0833
p.S838L	NCI-H1155	lung	COSMIC	ATSTS	DEG_SPOP_SBC_1	840:844	Mutation rewiring degron network	0.2778

Kaplan plot for ITSN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITSN2

UniProt ID: Q9NZM3

Entrez ID: 50618

Protein name: Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITSN2 in