DegronMD

Uniprot ID: Q9NZM3

Source protein: Intersectin-2

Source gene: ITSN2

Class: DEG_SPOP_SBC_1

Location: 162:166

E3 ligase: SPOP

DEGRON score: 0.9894

ASA_SCORE: 71.36

COIL: 0.927

CONS_SCORE: 0.2769

DSS_SCORE: 0.4432

HELIX: 0.0296

FCONS_SCORE: 0.9615

RIG_SCORE: 0.665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S166L	TCGA-96-A4JK	LUSC	TCGA	VSTSS	DEG_SPOP_SBC_1	0.7667
p.S166L	DO45442	LUSC	ICGC	VSTSS	DEG_SPOP_SBC_1	0.7667
p.P157L	TCGA-ER-A2NH	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	0.1944
p.P157L	DO47683	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1944
p.S161F	TCGA-FS-A1ZA	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	0.3056
p.S161F	DO37551	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	0.3056
p.A172T	DO233210	GACA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1667
p.S163N	DO233899	GACA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.5958
p.T171N	DO229036	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.1944
p.G170R	DO49142	PACA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.2222
p.P168Q	DO227710	PBCA	ICGC	VSTSS	DEG_SPOP_SBC_1	0.2778
p.V159L	ACH-000973	Bladder Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	0.25
p.A153V	ALL-PO	haematopoietic_and_lymphoid_tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_SPOP_SBC_1	339:343	VSTSS	SPOP	0.9784	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SPOP_SBC_1	816:820	VSTSS	SPOP	0.9961	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	38:42	VSTSS	SPOP	0.9947	More...
P57768	Sorting nexin-16	DEG_SPOP_SBC_1	33:37	VSTSS	SPOP	0.9979	More...
Q14149	MORC family CW-type zinc finger protein 3	DEG_SPOP_SBC_1	872:876	VSTSS	SPOP	0.9439	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	776:780	VSTSS	SPOP	0.6894	More...
Q6PJT7	Zinc finger CCCH domain-containing protein 14	DEG_SPOP_SBC_1	131:135	VSTSS	SPOP	0.9971	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	1333:1337	VSTSS	SPOP	0.961	More...
Q7L1W4	Volume-regulated anion channel subunit LRRC8D	DEG_SPOP_SBC_1	238:242	VSTSS	SPOP	0.6957	More...
Q86UE8	Serine/threonine-protein kinase tousled-like 2	DEG_SPOP_SBC_1	749:753	VSTSS	SPOP	0.9974	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	1839:1843	VSTSS	SPOP	0.9049	More...
Q8NFU7	Methylcytosine dioxygenase TET1	DEG_SPOP_SBC_1	569:573	VSTSS	SPOP	0.9917	More...
Q8TF72	Protein Shroom3	DEG_SPOP_SBC_1	815:819	VSTSS	SPOP	0.9994	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	162:166	VSTSS	SPOP	0.9894	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	888:892	VSTSS	SPOP	0.9942	More...
Q9Y4D8	Probable E3 ubiquitin-protein ligase HECTD4	DEG_SPOP_SBC_1	3049:3053	VSTSS	SPOP	0.9533	More...
Q9BQE6	LBH domain-containing protein 1	DEG_SPOP_SBC_1	51:55	VSTSS	SPOP	0.5933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons