DegronMD - P35716(SOX11)

GO - Biological processes (BP): anatomical structure morphogenesis [GO:0009653]; cardiac ventricle formation [GO:0003211]; cell differentiation [GO:0030154]; closure of optic fissure [GO:0061386]; cornea development in camera-type eye [GO:0061303]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic skeletal system morphogenesis [GO:0048704]; eyelid development in camera-type eye [GO:0061029]; glial cell development [GO:0021782]; glial cell proliferation [GO:0014009]; hard palate development [GO:0060022]; kidney development [GO:0001822]; lens morphogenesis in camera-type eye [GO:0002089]; limb bud formation [GO:0060174]; lung morphogenesis [GO:0060425]; negative regulation of cell death [GO:0060548]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of lymphocyte proliferation [GO:0050672]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; neural crest cell development [GO:0014032]; neural tube formation [GO:0001841]; neuroepithelial cell differentiation [GO:0060563]; neuron differentiation [GO:0030182]; noradrenergic neuron differentiation [GO:0003357]; oligodendrocyte development [GO:0014003]; outflow tract morphogenesis [GO:0003151]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of hippo signaling [GO:0035332]; positive regulation of hormone secretion [GO:0046887]; positive regulation of lens epithelial cell proliferation [GO:2001111]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; skeletal muscle cell differentiation [GO:0035914]; skeletal system development [GO:0001501]; soft palate development [GO:0060023]; somite development [GO:0061053]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; ventricular septum morphogenesis [GO:0060412] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A330T	TCGA-56-7823	LUSC	TCGA	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0833
p.A330T	DO223721	LUSC	ICGC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0833
p.D357N	TCGA-DA-A1I4	SKCM	TCGA	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.3056
p.D357N	DO37655	SKCM	ICGC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.3056
p.V339M	TCGA-DD-AACI	LIHC	TCGA	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7208
p.V339M	DO52205	LIHC	ICGC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7208
p.V339M	DO229268	THCA	ICGC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7208
p.S335T	TCGA-VB-A8QN	DLBC	TCGA	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2222
p.S335T	DO223730	DLBC	ICGC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2222
p.S347G	DO7990	COAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.2222
p.S347G	DO7990	COAD	ICGC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2222
p.S344F	DO222762	COCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.1389
p.S344F	DO222762	COCA	ICGC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.S344F	DO222662	MELA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.1389
p.S344F	DO222662	MELA	ICGC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.3056
p.S349T	DO223022	ESCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.2778
p.S349T	DO223022	ESCA	ICGC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1667
p.A358V	DO233867	GACA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.2778
p.G355D	DO23308	LINC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation altering degron motif	0.7198
p.L361P	DO38380	STAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.1944
p.L361P	ACH-000937	Leukemia	CCLE	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.1944
p.S349G	SIDM02041	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.2778
p.S349G	SIDM02041	Colorectal Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1667
p.S342P	SIDM00282	Colorectal Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.6752
p.S342P	ACH-000998	Colon/Colorectal Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.6752
p.D360N	SIDM00681	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	351:356	Mutation rewiring degron network	0.2222
p.S340T	SIDM00537	Colorectal Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.6005
p.S340T	ACH-000982	Colon/Colorectal Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.6005
p.S340T	ACH-001345	Colon/Colorectal Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.6005

Kaplan plot for SOX11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOX11

UniProt ID: P35716

Entrez ID: 6664

Protein name: Transcription factor SOX-11

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOX11 in