DegronMD

Uniprot ID: P35716

Source protein: Transcription factor SOX-11

Source gene: SOX11

Class: DEG_Kelch_Keap1_1

Location: 351:356

E3 ligase: KEAP1

DEGRON score: 0.9388

ASA_SCORE: 76.0167

COIL: 0.903

CONS_SCORE: 0.6304

DSS_SCORE: 0.611

HELIX: 0.0797

FCONS_SCORE: 1.0101

RIG_SCORE: 0.4636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D357N	TCGA-DA-A1I4	SKCM	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.D357N	DO37655	SKCM	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.S347G	DO7990	COAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.2222
p.S344F	DO222762	COCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.S344F	DO222662	MELA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.S349T	DO223022	ESCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.2778
p.A358V	DO233867	GACA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.2778
p.G355D	DO23308	LINC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.7198
p.L361P	DO38380	STAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1944
p.L361P	ACH-000937	Leukemia	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.1944
p.S349G	SIDM02041	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.2778
p.D360N	SIDM00681	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_Kelch_Keap1_1	351:356	SGSSGE	KEAP1	0.9388	More...
Q02156	Protein kinase C epsilon type	DEG_Kelch_Keap1_1	132:137	SGSSGE	KEAP1	0.8528	More...
Q9UGU5	HMG domain-containing protein 4	DEG_Kelch_Keap1_1	153:158	SGSSGE	KEAP1	0.9956	More...
Q6NUJ5	PWWP domain-containing protein 2B	DEG_Kelch_Keap1_1	382:387	SGSSGE	KEAP1	0.9831	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	DEG_Kelch_Keap1_1	544:549	SGSSGE	KEAP1	0.965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons