DegronMD - Q6NUJ5(PWWP2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E387K	TCGA-18-3414	LUSC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation altering degron motif	0.7022
p.E387K	DO26629	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation altering degron motif	0.7022
p.S382F	TCGA-GN-A26C	SKCM	TCGA	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation altering degron motif	0.7982
p.S382F	DO37782	SKCM	ICGC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation altering degron motif	0.7982
p.S381P	TCGA-IB-7651	PAAD	TCGA	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.3056
p.S381P	DO46657	PAAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.3056
p.R157H	TCGA-QH-A65V	LGG	TCGA	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.R157H	DO48668	LGG	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.S385L	TCGA-YD-A9TA	SKCM	TCGA	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation altering degron motif	0.7667
p.S385L	DO219503	SKCM	ICGC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation altering degron motif	0.7667
p.R159H	DO234199	ESAD	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.25
p.R159H	SIDM00876	Non-Cancerous	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.25
p.E179K	DO234334	ESAD	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0833
p.R157C	DO233227	GACA	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.T168I	DO233697	GACA	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7078
p.G375S	DO35442	PACA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.1389
p.G375S	SIDM02071	Esophageal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.1389
p.R153W	DO232224	PBCA	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0833
p.R172W	SIDM02059	Colorectal Carcinoma	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.2778
p.G397S	SIDM01096	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397S	SIDM01109	Other Sarcomas	GDSC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397S	SIDM00081	Melanoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397S	SIDM01475	Ovarian Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397S	SK-CO-1	large intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397D	SIDM00684	Glioblastoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397D	SIDM00555	Glioblastoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397D	ACH-000595	Brain Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397D	ACH-000631	Brain Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397D	KS-1	central nervous system	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.G397D	LN-229	central nervous system	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.0556
p.P395R	SIDM00002	Neuroblastoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.1111
p.P395R	ACH-002340	Neuroblastoma	CCLE	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.1111
p.P395R	NBsusSR	autonomic ganglia	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.1111
p.Q175R	SIDM00487	Colorectal Carcinoma	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.Q175R	ACH-000963	Colon/Colorectal Cancer	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.I165N	SIDM01059	Melanoma	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.6169
p.I165N	ACH-000915	Skin Cancer	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.6169
p.R170C	SIDM01619	Endometrial Carcinoma	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.719
p.R170C	ACH-000984	Endometrial/Uterine Cancer	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.719
p.Q175H	ACH-000855	Esophageal Cancer	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.Q175H	ACH-001541	Myeloma	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.G376R	ACH-001282	Bone Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	382:387	Mutation rewiring degron network	0.1667

Kaplan plot for PWWP2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PWWP2B

UniProt ID: Q6NUJ5

Entrez ID: 170394

Protein name: PWWP domain-containing protein 2B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PWWP2B in